Publications by authors named "Adriana Z Kita"
Tremendous knowledge has been gained in the understanding of various modifications of IgG antibodies, driven mainly by the fact that antibodies are one of the most important groups of therapeutic molecules and because of the development of advanced analytical techniques. Recombinant monoclonal antibody (mAb) therapeutics expressed in mammalian cell lines and endogenous IgG molecules secreted by B cells in the human body share some modifications, but each have some unique modifications. Modifications that are common to recombinant mAb and endogenous IgG molecules are considered to pose a lower risk of immunogenicity.
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- Lysosomal enzymes like GALNS are crucial for breaking down macromolecules, and deficiencies in these enzymes can lead to lysosomal storage disorders, such as MPS IV A (Morquio A).
- The three-dimensional structure of human GALNS was determined using X-ray crystallography, revealing a unique active site that can bind to certain substrates, and highlighting how specific mutations impact its function.
- The study found that most mutations in MPS IV A affect the enzyme's structure, leading to misfolding, and contrasted GALNS with related sulfatases to reveal conserved catalytic functions despite differing active-site structures.