Effects of benzene, quercetin, and their combination on porcine ovarian cell proliferation, apoptosis, and hormone release.

We hypothesized that the environmental contaminant benzene and the plant antioxidant quercetin may affect ovarian cell functions and that quercetin could offer protection against the adverse effects of benzene. This study aimed to examine the action of benzene, quercetin, and their combination on porcine ovarian granulosa cell functions. We elucidated the effects of benzene (20  g mL ), quercetin (at the doses 0, 1, 10, 100  g mL ), and their combination on ovarian granulosa cell functions (proliferation, apoptosis, and hormone release) in vitro using immunocytochemistry and enzyme immunoassay respectively.

Can xylene and quercetin directly affect basic ovarian cell functions?

Exposure to xylene leads to dysfunction of mammalian female reproduction. Quercetin present in vegetables contribute significantly to their role as health-promoting foods. The effects of xylene and quercetin on ovarian cell function, their interrelationships, and mechanisms of action are insufficiently studied.