Publications by authors named "Adriana R C Cenachi"
Background: Late-relapsing hepatitis after yellow fever (LHep-YF) during the convalescent phase of the disease has been described during recent yellow fever (YF) outbreaks in Brazil. LHep-YF is marked by a rebound in liver enzymes and nonspecific clinical manifestations around 46-60 days after YF symptom onset.
Methods: Here we have characterized the clinical course and risk factors for LHep-YF using data from a representative cohort of patients who survived YF in Brazil, 2017-2018.
Article Synopsis
- Yellow fever virus (YFV) causes yellow fever, a severe illness with a high fatality rate; analyzing cerebrospinal fluid (CSF) from Brazilian patients revealed insights into YFV's neuroinvasive potential.
- In a study of 13 patients from a 2018 outbreak, YFV RNA was found in 5 CSF samples, while anti-YFV IgM was present in 8 samples, indicating immune response and viral presence in the central nervous system.
- The findings suggest that YFV can potentially invade the nervous system, but more research is necessary to fully understand its effects on disease progression and neuroinvasiveness.