Publications by authors named "Adriana Quintana"
Article Synopsis
- New strategies are essential to improve blood pressure control rates, prompting the QUARTET USA trial to assess a four-drug combination therapy for hypertensive patients.
- The study involved 62 participants, who were randomly assigned to receive either a quadpill with lower doses of four blood pressure medications or a single higher dose of one medication over 12 weeks.
- Results showed no significant difference in systolic blood pressure between the two groups, though the quadpill led to greater reductions in diastolic blood pressure, indicating its potential effectiveness without increased adverse events.
Background: This convergent parallel-design mixed-methods process evaluation of the QUARTET USA (Quadruple Ultra-Low-Dose Treatment for Hypertension USA) clinical trial (NCT03640312) explores patient and health care professional perceptions about the use of low-dose quadruple therapy (LDQT) as a novel strategy for hypertension management.
Methods And Results: A survey of all 62 patients enrolled in the QUARTET USA trial was conducted. A subsample of 13 patients and 11 health care professionals, recruited via purposive sampling, took part in semistructured interviews.
Background: Over half of patients with elevated blood pressure require multi-drug treatment to achieve blood pressure control. However, multi-drug treatment may lead to lower adherence and more adverse drug effects compared with monotherapy.
Objective: The Quadruple Ultra-low-dose Treatment for Hypertension (QUARTET) USA trial was designed to evaluate whether initiating treatment with ultra-low-dose quadruple-combination therapy will lower office blood pressure more effectively, and with fewer side effects, compared with initiating standard dose monotherapy in treatment naive patients with SBP < 180 and DBP < 110 mm Hg and patients on monotherapy with SBP < 160 and DBP < 100 mm Hg.