Publications by authors named "Adriana Moreira Soares"
Background: Dengue is one of the most important re-emerging viral diseases and the most common human arthropod-borne viral infection worldwide. Any of the four Dengue virus serotypes (DENV-1 to 4) can cause asymptomatic infections or clinical manifestations that range in severity from a mild, self-limited illness, to a severe disease characterized by a shock syndrome that can lead to death. Paraguay suffers periodic epidemic outbreaks of dengue since 1988 when the DENV-1 was introduced in the country.
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- * Out of 110 children, 50.91% were suspected to have dengue, with a high confirmation rate (92.9%) among those suspected and 81.5% among those not suspected, leading to an overall confirmation of 87.27%.
- * Clinical diagnoses had a sensitivity of 54.2%, a specificity of 71.4%, and showed that saliva samples can be effective alternatives to blood for early dengue diagnosis, emphasizing the need for virological tests in dengue surveillance protocols.
Background: Several experimental animal models have been used to study the pathogenesis of dengue disease; however, most of the studies used laboratory-adapted viruses, which lack the virulence of viruses circulating in humans. The aim of this study was to analyze the ability of clinical Dengue virus (DENV) isolates (D2/BR/RP/RMB/09 and D3/BR/SL3/02) to infect immunocompetent C57BL/6 mice.
Methods: Two strategies of intraperitoneal infection, which were based on the concept of the antibody dependent enhancement phenomenon, were used.