Shear stress modulates inner blood retinal barrier phenotype.

The vascular endothelium responds to the shear stress generated by blood flow and changes function to maintain tissue homeostasis and adapt to injury in pathological conditions. Shear stress in the retinal circulation is altered in patients with retinal vascular diseases, such as diabetic retinopathy. Therefore, we aimed to study the effect of laminar shear stress on barrier properties and on the release of proinflammatory cytokines in human retinal microvascular endothelial cells (HRMEC).

Graphene-Dendrimer Nanostars for Targeted Macrophage Overexpression of Metalloproteinase 9 and Hepatic Fibrosis Precision Therapy.

Fibrosis contributes to ∼45% of all deaths in industrialized nations, but no direct antifibrotic therapeutic interventions exist to date. Graphene-based nanomaterials exhibit excellent versatility in electronics, and emerging trends exploit their properties for biomedical applications, especially for drug and gene delivery. We designed constructs of graphene nanostars linked to PAMAM-G5 dendrimer for the selective targeting and delivery of a plasmid expressing the collagenase metalloproteinase 9 under the CD11b promoter into inflammatory macrophages in cirrhotic livers.

Prospective study of a venom batch (Bj2015) - phospholipase A activity, immunogenicity, neurotoxicity, and myotoxicity parameters.

venom's (Bj2015) batch was biomonitored quarterly for one year to assess phospholipase A (PLA) activity, immunogenicity, neurotoxicity, and myotoxicity. models were applied to evaluate losses using decay model and recoveries by predictive trend analysis. Mice were immunized with Bj2015.