TNF-R2 expression in acquired middle ear cholesteatoma.

Unlabelled: Acquired middle ear cholesteatoma is a disease which promotes bone erosion resulting in potentially serious complications. The tumor necrosis factor alpha (TNF-α) is present in cholesteatoma and it is related to bone erosion, as shown by different authors. To understand the aggressiveness characteristics of cholesteatoma is necessary, however, to better address the presence and distribution of their receptors.

EGFR expression in acquired middle ear cholesteatoma in children and adults.

Middle ear cholesteatomas are characterized by the presence of keratinized stratified squamous epithelium inside this cavity. It is considered to be more aggressive in childhood. In normal skin, the epidermal growth factor receptor (EGFR) is expressed in the cytoplasmic membrane of epithelial cells of the basal layer.

Hyperproliferation markers in ear canal epidermis.

Unlabelled: Several studies involving immunohistochemical methods to assess external auditory canal epidermis have been performed with different objectives. With this method it is possible to assess the expression of various antigens such as cytokeratins, cytokines, and hyperproliferation markers among others.

Aim: to revise, describe and analyze the knowledge generated by identifiable papers published on the worldwide literature about immunohistochemical hyperproliferation markers in normal external auditory canal epidermis.

Analysis of histopathological aspects in acquired middle ear cholesteatoma.

Unlabelled: Middle ear cholesteatomas are characterized by the presence of stratified squamous epithelium in this cavity with highly invasive properties causing bone destruction and it may lead to complications.

Aim: To study the histopathological features in acquired cholesteatomas of the middle ear, correlating this data with patient age.

Study Design: clinical and experimental cross-sectional study.