Dynamics of Mismatch and Alternative Excision-Dependent Repair in Replicating DNA Examined Under Conditions of Neutral Selection.

Spontaneous DNA deamination is a potential source of transition mutations. In , EndoV, a component of the alternative excision repair pathway (AER), counteracts the mutagenicity of base deamination-induced mispairs. Here, we report that the mismatch repair (MMR) system, MutSL, prevents the harmful effects of HNO, a deaminating agent of Cytosine (C), Adenine (A), and Guanine (G).