Publications by authors named "Adriana Frohlich Mercadante"
Identification of novel putative-binding proteins for cellular prion protein and a specific interaction with the STIP1 homology and U-Box-containing protein 1.
Ana Paula Lappas Gimenez Larissa Morato Luciani Richter Mariana Campos Atherino Breno Castello Branco Beirão Celso Fávaro Adriana Frohlich Mercadante
Prion
September 2016
Article Synopsis
- Prion diseases involve the misfolding of the prion protein (PrP(C)) into an infectious form (PrP(Sc)), impacting the olfactory system and potentially leading to behavioral impairments in olfactory tests in mice lacking PrP(C).
- The study identified ten novel proteins that bind to PrP(C), which are involved in key cellular processes like proliferation, apoptosis, and stress response, highlighting PrP(C)'s role beyond just prion diseases.
- One of the identified binding partners, Stub1, has implications for neurodegenerative diseases due to its relationship with protein misfolding and may indicate a broader, significant role for PrP(C) in various biological functions across different tissues.
Broilers and layer chickens have been intensively selected for production parameters. This selection has affected immune capacity. Consequently, the fine-tuning of immune responses is becoming important for maximum productivity.
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