Publications by authors named "Adriana Costanzo"
Article Synopsis
- Glioblastoma (GBM) is a highly aggressive brain cancer that has poor treatment outcomes despite surgery, radiation, and chemotherapy.
- Antiangiogenic therapies, which target abnormal blood vessel growth in GBM, are often evaded due to the tumor's ability to undergo vasculogenic mimicry, a process where GBM forms its own blood supply.
- Research showed that histone deacetylase inhibitors (HDACis) like vorinostat and MC1568 effectively reduce tube formation and cell invasion in GBM, suggesting they could be valuable in targeting this alternate vascularization mechanism.
