Antioxidant and Anticancer Potential of the New Cu(II) Complexes Bearing Imine-Phenolate Ligands with Pendant Amine N-Donor Groups.

Cu(II) complexes bearing NNO-donor Schiff base ligands (, ) have been synthesized and characterized. The single crystal X-ray analysis of the complex revealed that a mononuclear and a dinuclear complex co-crystallize in the solid state. The electronic structures of the complexes are optimized by Density Functional Theory (DFT) calculations.

Synthesis, characterization, antioxidant potential, and cytotoxicity screening of new Cu(II) complexes with 4-(arylchalcogenyl)-1H-pyrazoles ligands.

Two new Cu(II) complexes based on 4-(arylchalcogenyl)-1H-pyrazoles monodentate bis(ligand) containing selenium or sulfur groups (2a and 2b) have been synthesized and characterized by IR spectroscopy, high-resolution mass spectrometry (HRMS), and by X-ray crystallography. In the effort to propose new applications for the biomedical area, we evaluated the antioxidant activity and cytotoxicity of the newly synthesized complexes. The antioxidant activity of the Cu(II) complexes (2a - 2b) were assessed through their ability to inhibit the formation of reactive species (RS) induced by sodium azide and to scavenge the synthetic radicals 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS).

Synthesis, molecular structure and antioxidant activity of bis [L(μ-chloro)copper(II)] supported by phenoxy/naphthoxy-imine ligands.

A new series of Cu(II) complexes [bis[{(μ-chloro)-2-MeO-Ph-CH-(N=CH)-2,4-tert-butyl-2-OCH)}Cu(II)] (Cu1); bis[{(μ-chloro)-2-MeS-Ph-CH-(N=CH)-2,4-tert-butyl-2-(OCH)}Cu(II)] (Cu2); bis[{(μ-chloro)-2-MeO-Ph-CH-(N=CH)-2-(OCH)} Cu(II)] (Cu3); bis[{(μ-chloro)-2-MeS-Ph-CH-(N=CH)-2-(OCH)}Cu(II)] complex (Cu4); bis[{2-MeS-Ph-CH-(N=CH)-2,4-tert-butyl-2-(OCH)}Cu(II)] (Cu5)] have been synthesized and characterized by elemental analysis, IR, UV-Visible and by X-ray crystallography for Cu1, Cu4 and Cu5. In the solid state, Cu1 features of a chloro-bridged dimer complex with κ coordination of the monoanionic phenoxy-imine ligand onto the copper center. On the other hand, the molecular structure of Cu4 reveals the naphthoxy-imine ligand with pendant S-group coordinated to the copper atom in tridentate meridional fashion.

Anisotropic self-organization of hybrid silica based xerogels containing bridged positively charged 1,4-diazoniabicycle[2.2.2]octane chloride group.

Anisotropic self-organized hybrid silica based xerogels were obtained. The ordered structure was imposed by the double charged 1,4-diazoniabicycle[2.2.