Respiratory mechanics do not always mirror pulmonary histological changes in emphysema.

Objective: To verify the accordance of functional and morphometric parameters during the development of emphysema.

Methods: BALB/c mice received a nasal drop of either papain or saline solution and were studied after 1, 3, 15, 28, and 40 days. Functional parameters, such as airway resistance, tissue damping, and tissue elastance, were analyzed.

Trend of maximal inspiratory pressure in mechanically ventilated patients: predictors.

Introduction: It is known that mechanical ventilation and many of its features may affect the evolution of inspiratory muscle strength during ventilation. However, this evolution has not been described, nor have its predictors been studied. In addition, a probable parallel between inspiratory and limb muscle strength evolution has not been investigated.