Publications by authors named "Adriana Amorim Torres"
Article Synopsis
- Fibroblast growth factor (FGF) is crucial for initiating neural gene activation in embryos, but the precise mechanisms of how it affects chromatin structure and gene regulation are not well understood.
- *Dephosphorylation of the FGF pathway's effector ERK1/2 enhances chromatin accessibility at neural genes, leading to premature transcription without initially losing repressive histone marks.
- *The study shows that stopping ERK1/2 signaling creates broader changes in chromatin and transcription factor binding, establishing a framework for direction in neuronal differentiation.*
Article Synopsis
- Scientists use special mice to study how genes work and find out more about diseases that can affect humans.
- One specific type of hearing loss is common in kids, and a new mouse model named "rodador" was created to help understand it better.
- The rodador mouse has a gene mutation that causes deafness and balance problems, which could lead to new discoveries about hearing loss in people.
Previous studies have suggested that γ-aminobutyric acid-B (GABA(B)) receptor agonists effectively reduce ethanol intake. The quantification using real-time polymerase chain reaction of Gabbr1 and Gabbr2 mRNA from the prefrontal cortex, hypothalamus, hippocampus, and striatum in mice exposed to an animal model of the addiction developed in our laboratory was performed to evaluate the involvement of the GABA(B) receptor in ethanol consumption. We used outbred, Swiss mice exposed to a three-bottle free-choice model (water, 5% v/v ethanol, and 10% v/v ethanol) that consisted of four phases: acquisition (AC), withdrawal (W), reexposure (RE), and quinine-adulteration (AD).
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