Publications by authors named "Adrian Villamarin-Ortiz"
PADI4 is one of the human isoforms of a family of enzymes implicated in the conversion of arginine to citrulline. MDM2 is an E3 ubiquitin ligase which is crucial for down-regulation of degradation of the tumor suppressor gene p53. Given the relationship between both PADI4 and MDM2 with p53-signaling pathways, we hypothesized they may interact directly, and this interaction could be relevant in the context of cancer.
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- RYBP is an intrinsically disordered protein involved in transcription regulation and shows potential interactions with the well-folded enzyme PADI4, which converts arginine to citrulline.
- The study found that RYBP and PADI4 associate in the nucleus and cytosol of cancer cell lines, and their binding was confirmed both in vitro and through other assays.
- This interaction may affect cancer cell proliferation when combined with PARP inhibitors, suggesting a possible role in cancer development through the citrullination of RYBP.