Publications by authors named "Adrian Peter Funke"
Article Synopsis
- The study focused on creating transdermal systems (TDSs) for delivering a highly lipophilic antiestrogen using permeation enhancers like propylene glycol and lauric acid.
- Results showed that pre-treating skin with these enhancers significantly increased the transdermal delivery of the antiestrogen, with the best results coming from Gelva polyacrylate adhesive.
- Two strategies were tested to improve TDS effectiveness: one involved adding hydroxypropyl cellulose to increase propylene glycol content, and the other used a fleece-laminated backing, both showing improved flux rates when applied to pre-treated skin.
Transdermal systems (TDS) are a well-known application form for small, moderately lipophilic molecules. The aim of this study was to investigate the possibility of applying a highly lipophilic drug, the antiestrogen AE (log P=5.82) transdermally by polyacrylate-based matrix TDS.
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