Publications by authors named "Adrian P Merce"
Cardiovascular diseases represent the major cause of morbidity mainly due to chronic heart failure. Epicardial (EAT) and perivascular adipose tissues (PVAT) are considered major contributors to the pathogenesis of cardiometabolic pathologies. Monoamine oxidases (MAOs) are mitochondrial enzymes recognized as sources of reactive oxygen species (ROS) in cardiometabolic pathologies.
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- * The study explored how the antidiabetic drugs metformin and empagliflozin affect MAO expression, oxidative stress, and blood vessel function in internal mammary arteries from overweight patients undergoing bypass surgery.
- * Results showed that high glucose and angiotensin II increased MAO expression and oxidative stress, leading to impaired blood vessel function, but metformin and empagliflozin mitigated these effects when used separately, without any added benefit when combined.
Article Synopsis
- * High-resolution respirometry (HRR) is a modern technique that analyzes mitochondrial respiration and helps identify its impairments in relation to health and disease.
- * The review highlights how mitochondrial bioenergetics change in key organs involved in obesity and diabetes, emphasizing that mitochondrial dysfunction and insulin insensitivity influence each other in these conditions.
Diet-induced metabolic diseases, such as obesity, metabolic syndrome, and type 2 diabetes (T2DM) are the global threatening epidemics that share cardiovascular oxidative stress as common denominator. Monoamine oxidase (MAO) has recently emerged as a constant source of reactive oxygen species (ROS) in DM. Metformin, the first-line drug in T2DM, elicits cardiovascular protection via pleiotropic effects.
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