The pattern of bifurcated hydrogen bonds in thiourea cocrystals with diazine derivatives: experimental and quantum theoretical studies.

Cocrystals of thiourea with pyrazine N-oxide as thiourea-pyrazine N-oxide (2/1), CHNO·2CHNS, (I), and with phenazine as thiourea-phenazine (6/7), 7CHN·6CHNS, (II), both crystallize in the monoclinic space group P2/c. In the crystalline state, molecules of both components are linked by N-H..

Pyrazine-2(1)-thione.

The title compound, CHNS, was obtained by the reduction of 2-mercapto-pyrazine (during its crystallization with 2-mercapto-pyrazine and isonicotinic acid -oxide in ethanol solution. It crystallizes in the monoclinic space group P. In the crystal, the mol-ecules are linked by N-H⋯N and C-H⋯S hydrogen bonds.

Familial Hypercholesterolaemia in a Bulgarian Population of Patients with Dyslipidaemia and Diabetes: An Observational Study.

Introduction: Patients with diabetes and familial hypercholesterolaemia (FH) are at very high risk of cardiovascular events, but rates of FH detection are very low in most countries, including Bulgaria. Given the lack of relevant data in the literature, we conducted a retrospective observational study to (1) identify individuals with previously undiagnosed FH among patients being treated at Bulgarian diabetes centres, and (2) gain insight into current management and attainment of low-density lipoprotein cholesterol (LDL-C) goals in such patients.

Methods: From a database of diabetes centres across Bulgaria we retrieved medical records from patients aged ≥ 18 years with type 1/2 diabetes mellitus (T1DM/T2DM) who were being treated with insulin/insulin analogues, dipeptidyl peptidase 4 inhibitors, glucagon-like peptide 1 receptor agonists and/or sodium-glucose co-transporter-2 inhibitors.