Publications by authors named "Adrian Lene-McKay"
Article Synopsis
- Researchers studied early-onset urinary tract disorders like urofacial syndrome (UFS), which is caused by a mutation affecting bladder function and can lead to kidney failure.
- Current treatments don't address the core issues of these disorders, prompting the exploration of a gene therapy approach using an adeno-associated viral (AAV9) vector to deliver the missing gene in neonatal mice.
- The treatment successfully expressed the missing protein in the pelvic ganglia and improved bladder function, suggesting that AAV9 gene therapy may offer a potential cure for UFS and related neurogenic bladder issues.
