Publications by authors named "Adrian Herod"
Shigellosis remains a major cause of severe diarrheal disease and death throughout the world. Vaccine development against shigellosis has been hampered by an incomplete understanding of the molecular mechanisms by which Shigella spp. causes disease and difficulties in manipulating Shigella spp.
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- Photodynamic inactivation (PDI) is a technique that uses a photosensitizer, like the botanical extract PhytoQuin, along with light and oxygen to generate reactive oxygen species (ROS) that can inactivate microorganisms, including viruses.
- Research has shown that photoactivated PhytoQuin has antiviral effects against human coronaviruses, specifically HCoV-229E and HCoV-OC43, inhibiting their replication in cultured cells in a light-dependent manner.
- The study also found that PDI damages the viral integrity of coronaviruses, allowing for the breakdown of their RNA, and identified emodin, a component of PhytoQuin, as being critical to its antiviral activity.
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- Salmonella is a diverse foodborne pathogen with over 2,600 serovars, but not all cause severe diseases; their varying genetic backgrounds affect virulence.
- Key to Salmonella's infection strategy are E3 ubiquitin ligases delivered into host cells via a Type 3 Secretion System, with the first identified in this pathogen being the NEL-domain effectors.
- Recent findings highlight SspH1's role in degrading the mammalian protein PKN1 during macrophage infection, but this process doesn't influence Akt signaling; a newly identified gene, sspH3, is also linked to these NEL-domain effectors.
Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unknown. Here we show that in interferon-γ-stimulated cells guanylate-binding proteins (GBPs) assemble on the surface of Gram-negative bacteria into polyvalent signaling platforms required for activation of caspase-4.
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- - A study analyzed more than 2,600 serovars of bacteria to explore the links between genetic differences and their ability to cause disease, aiming to create a predictive model for virulence.
- - Researchers evaluated 35 strains from the SalFoS collection using various infection models, including tests on human cells and mice, to identify signs of virulence and correlate them with genomic data.
- - Findings revealed significant correlations in virulence predictions based on genomic information, providing a new strategy for assessing risks and monitoring bacterial strains linked to foodborne illnesses.
Recall of microbial-contaminated food products is an important intervention in preventing the transmission of foodborne illness. Here, we summarize the number and nature of foods recalled as a result of microbial contamination, classified by the Canadian Food Inspection Agency, for the period 1 January 2000 through 31 December 2017. A total of 10,432 food products were recalled from 2,094 recall events in Canada because of microbial contamination during this period.
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