Automated age- and sex-specific volumetric estimation of regional brain atrophy: workflow and feasibility.

Objectives: An automated workflow for age- and sex-specific estimation of regional brain volume changes from structural MRI relative to a standard population is presented and evaluated for feasibility.

Methods: T1w MRI scans are preprocessed in a standardized way comprising gray matter (GM) segmentation, normalization, modulation, and spatial smoothing. Resulting GM images are then compared to precomputed age- and sex-specific GM templates derived from the population-based Nathan Kline Institute Rockland Sample, and voxel-wise z-maps are compiled.

Subspecialization in the human posterior medial cortex.

The posterior medial cortex (PMC) is particularly poorly understood. Its neural activity changes have been related to highly disparate mental processes. We therefore investigated PMC properties with a data-driven exploratory approach.