Publications by authors named "Adrian Hase"

Article Synopsis
  • A meta-analysis was conducted to evaluate whether psychoplastogens like ketamine and psychedelics increase peripheral BDNF levels in humans, which have been suggested as biomarkers for neuroplasticity.
  • The analysis included data from 29 studies and found no significant evidence that these substances elevate peripheral BDNF levels, regardless of various factors such as drug type, dosage, or participant characteristics.
  • The findings imply that peripheral BDNF may not be a reliable marker for assessing neuroplasticity changes in humans after psychoplastogen administration, highlighting potential discrepancies between preclinical and human studies.
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Article Synopsis
  • * The study involved 46 unmedicated young adults with current or past MDD and 20 healthy controls, measuring GSH levels in the left prefrontal cortex and assessing depressive symptoms and cortisol levels, a stress marker.
  • * Findings revealed that individuals with current MDD had higher GSH levels than those with past MDD and controls, indicating that increased GSH may signify a temporary neurobiological change linked to reduced positive emotions rather than a long-term trait.
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Deficits in socio-emotional reciprocity, in prosocial behavior and in developing social relationships are diagnostic criteria of autism spectrum disorder (ASD), usually assessed by self-report or observation. Simple social experiments developed by behavioral economists allow for quantification of ASD-related social behavior. In this study, we used such experiments to compare social-economic decision-making between ASD adolescents and neurotypical controls.

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Rationale And Objectives: Differences among psychedelic substances regarding their subjective experiences are clinically and scientifically interesting. Quantitative linguistic analysis is a powerful tool to examine such differences. This study compared five psychedelic substance report groups and a non-psychedelic report group on quantitative linguistic markers of psychological states and processes derived from recreational use-based online experience reports.

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Introduction: This paper describes the implementation of a pilot project in Kurdistan / Northern Iraq on the use of EMDR in children in post-conflict settings.

Methods: A 4-field scheme aimed at patient stabilisation was taught to social workers for the application with children and adolescents in Northern Iraq. If possible, the stabilisation was followed by procedures aimed at memory reprocessing or modification within the eightphase EMDR protocol and (in all cases) with further care.

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  • The study investigates how psychological task engagement affects performance and cardiovascular responses during gaming, particularly in FIFA 19.
  • Low psychological task engagement is linked to less heart rate reactivity, suggesting that when players are less mentally invested, their physical responses are also diminished.
  • The findings indicate that previous game performance influences engagement levels, with poorer performance leading to increased engagement in subsequent matches, highlighting a connection between past outcomes and current motivation.
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  • Witnessing intergroup exclusion negatively impacts members of the excluded group, leading to feelings of personal exclusion and increased distress and aggression, particularly among individuals with collective narcissism.
  • A lab-based experiment found that witnessing a national majority being excluded by a minority heightened feelings of vicarious exclusion and aggressive behavior, as measured in a specific behavioral task.
  • While a mindful decentration intervention was expected to mitigate stress, it actually heightened emotional arousal in collective narcissists, indicating it may not be an effective coping strategy for those particularly sensitive to threats against their group's image.
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The biopsychosocial model of challenge and threat specifies a challenge-threat continuum where favorable demand-resource evaluations, efficient cardiovascular responses, and superior performance characterize challenge; and maladaptive outcomes like clinical depression characterize threat states. The model also specifies task engagement, operationalized as heart rate and ventricular contractility increases, as a prerequisite for challenge and threat states. The blunted cardiovascular reactivity to stress literature describes reductions of these increases and associates them with problems like clinical depression.

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Viewing stressful situations as more of a challenge than a threat (i.e., coping resources match or exceed situational demands) has been associated with better performance and long-term health.

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Eye movement desensitization and reprocessing (EMDR) is a well-established treatment for post-traumatic stress disorder. Recent research suggested that it may be effective in treating depressive disorders as well. The present study is part of a multicenter randomized-controlled trial, the EDEN study, in which a homogenous group of 30 patients was treated to test whether EMDR plus treatment as usual (TAU) would achieve superior results compared to TAU only in a psychosomatic-psychotherapeutic inpatient treatment setting.

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Background: Depression is a severe mental disorder that challenges mental health systems worldwide as the success rates of all established treatments are limited. Eye Movement Desensitization and Reprocessing (EMDR) therapy is a scientifically acknowledged psychotherapeutic treatment for PTSD. Given the recent research indicating that trauma and other adverse life experiences can be the basis of depression, the aim of this study was to determine the effectiveness of EMDR therapy with this disorder.

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The amino acid tyrosine is the precursor to the catecholamine neurotransmitters dopamine and norepinephrine. Increasing tyrosine uptake may positively influence catecholamine-related psychological functioning. We conducted a systematic review to examine the effects of tyrosine on behavior and cognition.

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