Population Pharmacokinetics of Gentamicin in Mexican Children With Severe Malnutrition.

Background: To develop a population pharmacokinetic model of gentamicin in children with complicated severe malnutrition and to study the influence of covariates (weight and age) on pharmacokinetic indices. In addition, we use the model to perform Monte Carlo simulations to explore the efficacy of several dosage regimens.

Methods: Twenty-six children with severe complicated malnutrition were studied.

Effect of severity disease on the pharmacokinetics of cefuroxime in children with multiple organ system failure.

The aim of the present study was to investigate if the severity of illness affected the pharmacokinetics of cefuroxime in 11 children diagnosed with multiple organ system failure. The patients were assigned to a severely ill group (group 1), a very severely ill group (group 2), or a control group (group 0). Blood samples were taken and cefuroxime concentrations were measured in plasma by HPLC after the first intravenous infusion of 100 mg of cefuroxime per kg of body weight.

Parenteral nutrition given to children and adults: experience of a procedure applied in Mexico.

Nutritional support is a critical step in caring for hospitalized patients both to avoid possible metabolic alterations that would worsen the patient's condition, or as a direct result of a particular disease. The purpose of the present study was to describe a procedure for the prescription of total parenteral nutrition (TPN), its administration, monitoring and the complications experienced in a third level hospital in Mexico, as applied to pediatric and adult patients given TPN. The study was carried out for a period of 30 months.

Levels of glutathione and some biogenic amines in the human brain putamen after traumatic death.

Mexico City is among the world's largest metropolitan city centers and one of the most difficult and challenging cities in which to drive a motor vehicle. During peak transit hours and maximum congestion, numerous accidents occur, many of them fatal. The aim of the study presented here was to analyze the levels of select indicators against oxidative stress and levels of biogenic amines as a consequence of accident or altercation and fear deaths.

Effect of age on the pharmacokinetics of ranitidine in healthy Mexican volunteers.

Unlabelled: Numerous reports in the literature have demonstrated changes in drug pharmacokinetics that result with age. Ranitidine is a drug commonly used in Mexico. However no reports on the pharmacokinetics of ranitidine in the Mexican population are available in the literature.

Pharmacokinetics and metabolic rates of acetyl salicylic acid and its metabolites in an Otomi ethnic group of Mexico.

The objective of this study was to determine pharmacokinetic differences of acetyl salicylic acid (ASA) and its metabolites: gentisic acid (GA), salicylic acid (SA) and salicyluric acid (SUA) between Otomies and Mesticians healthy subjects. Design. Ten Otomies and 10 Mesticians were included.

Effects of gender and phase of the menstrual cycle on the kinetics of ranitidine in healthy volunteers.

The present study was undertaken to determine if differences exist in the pharmacokinetic parameters of oral ranitidine caused by gender and stage of the menstrual cycle. The study was performed in two steps, in the first a pharmacokinetic study was performed on 10 men (average age 35.5 yrs) and 10 women (average age 34.