Bone Regeneration and Oxidative Stress: An Updated Overview.

Bone tissue engineering is a complex domain that requires further investigation and benefits from data obtained over past decades. The models are increasing in complexity as they reveal new data from co-culturing and microfluidics applications. The in vitro models now focus on the 3D medium co-culturing of osteoblasts, osteoclasts, and osteocytes utilizing collagen for separation; this type of research allows for controlled medium and in-depth data analysis.

Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review.

In the last decades, the treatment of primary and secondary bone tumors has faced a slow-down in its development, being mainly based on chemotherapy, radiotherapy, and surgical interventions. However, these conventional therapeutic strategies present a series of disadvantages (e.g.

Arthroscopical and histological study of cartilaginous lesions treated by mosaicplasty.

Aim: The aim of our study was to assess macro- and microscopically the knee cartilaginous lesions outcome treated by mosaicplasty.

Material And Method: Our study included 32 patients who underwent mosaicplasty for nondegenerative cartilaginous lesions of the knee and a second look arthroscopy. In 21 patients, minibiopsies from the repaired lesion were performed under arthroscopic control (from the cartilaginous region of the transplanted osteocartilaginous grafts and from the spaces between grafts).