Improving Access to Sexual Health Services in General Practice Using a Hub-and-Spoke Model: A Mixed-Methods Evaluation.

Improving access to sexual health services is critical in light of rising sexually transmitted infections (STIs). We evaluated a hub-and-spoke model for improving access to sexual health services in three general practices in Victoria, Australia. The primary outcome was the impact on HIV and STI (chlamydia, gonorrhoea, syphilis) testing.

Shear heating reconciles thermal models with the metamorphic rock record of subduction.

Some commonly referenced thermal-mechanical models of current subduction zones imply temperatures that are 100-500 °C colder at 30-80-km depth than pressure-temperature conditions determined thermobarometrically from exhumed metamorphic rocks. Accurately inferring subduction zone thermal structure, whether from models or rocks, is crucial for predicting metamorphic reactions and associated fluid release, subarc melting conditions, rheologies, and fault-slip phenomena. Here, we compile surface heat flow data from subduction zones worldwide and show that values are higher than can be explained for a frictionless subduction interface often assumed for modeling.

Risk factors for cytomegalovirus disease in seropositive renal transplant recipients; a single-center case-controlled study.

Background: Risk factors for cytomegalovirus (CMV) disease in renal transplant recipients have been evaluated in industrialized countries with relatively low CMV seroprevalence.

Objectives: We aimed to determine which factors are related to this illness in a high CMV seroprevalence country.

Patients And Methods: A case-control study was performed with data from a 5-year follow-up of 260 kidney transplant recipients at our center.

Eye dominance and response latency in area V1 of the monkey.

We measured the latency of 35 cells from V1 in two rhesus monkeys, to dynamic random dot stimuli monocular and binocularly presented. Mean latencies after non-dominant eye stimulation (97.9 ms) were longer than those for dominant eye (78.

Evaluation of retinal digital images by a general practitioner.

Diabetes and systemic hypertension are among the most prevalent diseases in developed countries. Since both can produce retinal involvement, they often cause long waiting lists for ophthalmologist consultation. The inspection of digital eye fundus images by a general practitioner would help to divert only those cases with retinal involvement.

Sensitivity to direction and orientation of random dot stereobars in the monkey visual cortex.

We are able to judge the direction of movement and orientation of objects because they have contrast-defined edges. However, we are also able to perceive the orientation and direction of movement of stereobars made of random dot stereograms in the absence of contrast-defined edges. We recorded 207 disparity-sensitive cells from visual areas V1 and V2 of two Macaca mulatta monkeys while performing an attentive fixation task.

Temporal characteristics of visual receptive fields in primary visual cortex and medial superior temporal cortex areas.

We mapped the receptive fields of 49 cells from primary visual cortex and 19 cells from medial superior temporal cortex in two awake monkeys. The receptive field structures we obtained lasted a mean time of 32.7 ms in primary visual cortex and 38.

Measurements of the periocular facial area with Web-based software.

We developed a simple Web-based program to make measurements on displayed photographs between several ocular and periocular landmarks. The measurements were: (1) vertical distance between the margin of the upper and lower eyelids (palpebral aperture), (2) distance between the lower eyelid margin and the inferior corneal margin (palpebro-limbar distance); (3) interpupillary distance; (4) ocular proptosis. We measured the distances using the Web program and compared them with manual measurements on the subject's face.

Publication output in telemedicine in Spain.

We searched the MEDLINE database for publications about telemedicine from 1966 to 2003. Only publications with a first institutional address in Spain and from journals listed in the JCR Science Edition 2002 were included in the study. A total of 118 publications were found.

Retinal correspondence of monocular receptive fields in disparity-sensitive complex cells from area V1 in the awake monkey.

Purpose: To explore the neural mechanisms underlying disparity sensitivity in complex cells of the macaque visual cortex, the relationship between interocular receptive field (RF) positional shift and disparity sensitivity was studied in area V1.

Methods: Single-unit recordings were made from area V1 of awake Macaca mulatta. Monocular RFs were mapped by means of a reverse cross-correlation technique, and their centers were determined after performing a bidimensional Gaussian function fitting.

Enhanced antilymphoma efficacy of CD19-redirected influenza MP1-specific CTLs by cotransfer of T cells modified to present influenza MP1.

To enhance the in vivo antitumor activity of adoptively transferred, CD19-specific chimeric antigen receptor (CAR)-redirected cytotoxic T lymphocytes (CTLs), we studied the effect of restimulating CAR(+) CTLs through their endogenous virus-specific T-cell antigen receptor (TcR) by the cotransfer of engineered T-cell antigen-presenting cells (T-APCs). Using influenza A matrix protein 1 (MP1) as a model antigen, we show that ex vivo-expanded CD4(+) and CD8(+) T-APCs expressing a hygromycin phosphotransferase-MP1 fusion protein (HyMP1) process and present MP1 to autologous human leukocyte antigen (HLA)-restricted, MP1-specific CD4(+) and CD8(+) CTL precursors. The MP1-specific CTLs are amenable to subsequent genetic modification to express a CD19-specific CAR, designated CD19R, and acquire HLA-unrestricted reactivity toward CD19(+) leukemia and lymphoma tumor targets while maintaining HLA-restricted MP1 specificity.