Publications by authors named "Adrian Bahn-Suh"
Multidrug-resistant (MDR) Enterococcus faecalis are major causes of hospital-acquired infections. Numerous clinical strains of E. faecalis harbor a large pathogenicity island that encodes enterococcal surface protein (Esp), which is suggested to promote biofilm production and virulence, but this remains controversial.
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Article Synopsis
- No vaccine is currently available for group A Streptococcus (GAS), a major cause of illness and death worldwide, primarily due to the high variability of its M protein with over 200 types.
- Neutralizing antibodies usually target specific parts of the M protein, offering limited protection, while human C4b-binding protein (C4BP) can recognize about 90% of the M protein variations.
- Researchers determined the structures of several M proteins bound to C4BP, revealing a unique mechanism that allows C4BP to detect common patterns amidst the variability, suggesting new strategies for drug development and vaccine creation.