Vitamin D receptor FokI polymorphism as a risk factor for painful diabetic neuropathy in type 2 diabetes mellitus patients.

Painful diabetic neuropathy (PDN) is a common complication in patients with type 2 diabetes mellitus (T2DM) with disruption of vitamin D (VD) activity as one of the risk factors. Active VD exerts its biological functions through the vitamin D receptor (VDR), which polymorphisms in the VDR gene can impair. This study aims to establish VDR FokI and ApaI polymorphisms as risk factors for PDN.

Helminthiasis in school-age children from Gresik, East Java, Indonesia.

This study aims to investigate the soil-transmitted helminth infection among school-age children in Gresik, East Java, Indonesia. An analytical observational study with a cross-sectional design was conducted from July to November 2023 in selected elementary schools in Gresik, East Java, Indonesia. Logistic regression analysis was employed to assess the impact of each risk factor on the likelihood of infection transmission.

Salmonella-induced pericarditis.

Introduction: Salmonella-induced pericarditis (SIP) is a rare complication of Salmonella infection, with only 30 cases reported to date, and a mortality rate of 14.8%. It is mostly associated with immunosuppression and can result in complications such as pericardial effusion, cardiac tamponade, and myopericarditis.

Management of Advanced Thymoma Presenting with Myasthenia Gravis in a Resource-limited Setting: A Case Report.

Thymomas are rare tumours which generally account for only 0.2 - 1.5% of mediastinal tumours in adults.

Comparative study of bovine and synthetic hydroxyapatite in micro- and nanosized on osteoblasts action and bone growth.

Hydroxyapatite (HA) is widely used as a bone graft. However, information on the head-to-head osteoinductivity and in vivo performance of micro- and nanosized natural and synthetic HA is still lacking. Here, we fabricated nanosized bovine HA (nanoBHA) by using a wet ball milling method and compared its in vitro and in vivo performance with microsized BHA, nanosized synthetic HA (nanoHA), and microsized synthetic HA (HA).

Turmeric-black pepper-honey nanoemulsion formulation and antiulcerogenic effect evaluation against ethanol-induced gastric ulcers in rats.

Gastric ulcer is a common disorder of the digestive system. The combination of turmeric and honey is known to treat stomach ulcers. However, curcumin, an active component in turmeric, has limitations, i.

Drug screening for ischemic stroke using larvae and adult zebrafish model: a review.

Ischemic stroke (IS) is the most recorded case of stroke that is caused by decreased blood flow to the brain. Nowadays, therapeutical agents for IS are limited and they have not shown maximum clinical results. Therefore, the exploration of new candidates for IS treatment continues to be done.

Pharmacology, phytochemistry and toxicity of a review.

belongs to the Ophioglosaceae family is referred to as in China. Historically, this terrestrial plant has been utilised for its anti-inflammatory properties and treatment of various ailments, with several scientific studies corroborating its efficacy. Compounds involved in it pharmacoloogy activities are Ugonin (U,J,K,M) and Neougonin A.

Neuroinflammation mechanism underlying neuropathic pain: the role of mesenchymal stem cell in neuroglia.

Pain is an essential aspect of the body's physiological response to unpleasant noxious stimuli from either external sustained injuries or an internal disease condition that occurs within the body. Generally, pain is temporary. However, in patients with neuropathic pain, the experienced pain is persistent and uncontrollable, with an unsatisfactory treatment effectiveness.

and studies of the potential cytotoxic, antioxidant, and HMG CoA reductase inhibitory effects of chitin from Indonesia mangrove crab () shells.

This study aimed to characterize chitin extracted from Indonesia mangrove crab () shells, as well as to assess its cytotoxic, antioxidant, and HMG CoA reductase inhibitory potentials. molecular docking, molecular dynamic, and ADMET prediction analyses were also carried out. Chitin was extracted from mangrove crab shells using deproteination and demineralization processes, Scanning Electron Microscopy (SEM) and Fourier Transform Infrared (FTIR) characterization are then performed.

One Health approach and zoonotic diseases in Indonesia: Urgency of implementation and challenges.

The urgency of implementing the One Health approach to overcome zoonotic diseases cannot be overstated. By recognizing the interconnectedness of human health, animal health, and the environment, we can effectively prevent and respond to emerging infectious disease threats. This review article provides information on the importance of generating research on zoonotic diseases, especially in Indonesia, where research is still relatively scarce.

Cucumber ( L.) Fruit and Combination with Losartan Attenuate the Elevation of Blood Pressure in Hypertensive Rats Induced by Angiotensin II.

Objectives: L. () is vegetable commonly used for managing blood pressure and often consumed in combination with standard antihypertensive therapy, despite lack of scientific evidence supporting their use. Combination of herbs and standard medication could have positive or negative effects.

Hepatoprotective Properties of Water Kefir: A Traditional Fermented Drink and Its Potential Role.

The liver is extremely vulnerable to damage because of its role in metabolism. Toxin, metabolic syndrome, alcohol, microorganisms, and autoimmune diseases can be the cause of liver damage. While different etiologies can cause liver disease, pathophysiologically, there are similarities in the role of free radicals, inflammatory mediators, and gut microbiome during the disease development.

In Vivo Pharmacodynamics of as Antiobesity with In Silico Molecular Docking and ADME/Pharmacokinetic Prediction Studies.

This study aims to determine the antiobesity activity of leaves extract (CSLE) on high fat diet-fed rats (HFD) and to predict the molecular docking and pharmacokinetics of selected compounds of to fat mass and obesity-associated protein (FTO). Daily body weight, organ, carcass fat (renal and anal), body mass index, total cholesterol, and total triglyceride levels were observed after CSLE was given orally for 50 days. Furthermore, body mass index of a CSLE dose of 50 mg/kgbw, 100 mg/kgbw and orlistat (120 mg/kgbw) group are 0.

Day-3 vs. Day-5 fresh embryo transfer.

Objective: Embryo transfer on day-5 has been associated with higher success rates, therefore our IVF clinics started to extend embryo culture until blastocyst stage. This study aimed to compare the success rates of day-3 vs. day-5 embryo transfers.

Comparison Epidemiology between Tuberculosis and COVID-19 in East Java Province, Indonesia: An Analysis of Regional Surveillance Data in 2020.

Tuberculosis and COVID-19 are among the infectious diseases that constitute a public health concern. Therefore, this study aims to examine the recent epidemiology of tuberculosis and COVID-19 in East Java Province, Indonesia, in 2020. Case-based surveillance data were acquired with a retrospective design between January and December 2020 by the East Java Health Officer.

Inhibitory activity of xanthoangelol isolated from Ashitaba ( Koidzumi) towards α-glucosidase and dipeptidyl peptidase-IV: and studies.

In Indonesia, the sap Koidzumi has been utilized traditionally as a blood-sugar reducer, nonetheless, its molecular mechanism still needs to be studied. This study aimed to isolate xanthoangelol (XA) from the yellow sap of planted in Mount Rinjani, Indonesia, and to investigate its mechanism by and methods towards α-glucosidase and dipeptidyl peptidase-IV (DPP-IV). The dried yellow sap was macerated using ethanol, subjected to liquid-liquid extraction using a different polarity of solvents, further gradient-eluted with column chromatography.

extracts stimulates bone healing in alveolar socket following tooth extraction.

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Anti-neuropathic Pain Mechanistic Study on Essential Oil, Precocene II, Caryophyllene, or Longifolene as Single Agents and in Combination with Pregabalin.

Background: Neuropathic pain has become a contributor to the global burden of illness. However, the currently available drugs exhibit inadequate pain relief and significant side effects. Our previous study demonstrated that the essential oil of Ageratum conyzoides exerts potent antineuropathic pain activity through opioid receptor activation.

Molecular docking studies of α-mangostin, γ-mangostin, and xanthone on peroxisome proliferator-activated receptor gamma diphenyl peptidase-4 enzyme, and aldose reductase enzyme as an antidiabetic drug candidate.

α-mangostin, γ-mangostin, and xanthone are some of the marker compounds found in mangosteen ( Linn.) whose activity on several treatment targets including toward the peroxisome proliferator-activated receptor gamma (PPAR-γ) receptors, diphenyl peptidase 4 (DPP-4) enzyme, and aldose reductase enzyme is unknown. Although this plant has been predicted to be used as an alternative antidiabetic treatment, it has been proven through several previous studies.

Neurologic manifestations of COVID-19 infection in Asia: a systematic review.

Background: COVID-19 infection can show various manifestation, including neurologic manifestations, such as , , or , and causes the neurologic disorder such as stroke, Guillain-Barre syndrome, encephalopathy, and many more.

Aim: To briefly review neurologic manifestation in COVID-19 infection in the Asia region (South East Asia and the Western Pacific Region).

Material And Methods: This review uses the PRISMA statement and checklist.

Impact of body mass index on intracytoplasmic sperm injection in women with polycystic ovary syndrome.

Polycystic ovary syndrome (PCOS) is a condition that affects fertility. There are two types of PCOS; the normal/lean type and overweight/obese type. The aim of this study was to assess baseline characteristics, ovarian response, quality of oocytes, embryos, pregnancy, implantation and live birth rates in normal/lean and overweight/obese patients with PCOS undergoing ICSI compared with patients without PCOS.

Anti-Neuropathic Pain Activity of Ageratum conyzoides L due to the Essential Oil Components.

Background: Neuropathic pain is one of the contributors to the global burdens of illness. At present many patients do not achieve satisfactory pain relief even with synthetic painkillers. Taking this into consideration, it is necessary to search for natural product-derived alternative treatment with confirmed safety and efficacy.

Isolation and Characterization of Phenylpropanoid and Lignan Compounds from [L.] Kunth with Estrogenic Activities.

Extracts of [L.] Kunth have previously been demonstrated to have in vivo estrogenic-like effects, thereby functioning as an anti-osteoporotic agent. However, the compounds responsible for these effects have not yet been determined.