Publications by authors named "Adnane Karami"
Article Synopsis
- Hepatitis A virus (HAV) is a major cause of acute hepatitis, especially in developing countries like Morocco, where many are exposed during childhood; studying circulating strains is vital for controlling outbreaks.
- In a study of 618 suspected cases, 162 tested positive for HAV, and subsequent analyses revealed a 26.2% infection rate and a 45% viraemia rate among those tested further.
- Phylogenetic analysis showed two circulating subgenotypes of HAV (IA and IB), with IA being the most prevalent at 87%, highlighting the genetic diversity of the virus in Morocco.
The outcomes of HBV and HCV infections are associated both with viral and host genetic factors. Here, we explore the role of a genetic variation located in membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) gene on spontaneous clearance of HBV and HCV infections and on liver fibrosis. We genotyped MBOAT7 rs641738 polymorphism in 971 consecutive Moroccan subjects, including 288 patients with chronic hepatitis C (CHC), 98 cases with spontaneous clearance of HCV, 268 patients with chronic hepatitis B (CHB), 126 spontaneously cleared HBV infections and 191 healthy controls.
View Article and Find Full Text PDF