Publications by authors named "Adnan Y Chowdhury"
Article Synopsis
- Aging affects our immune system because of changes in stem cells that regenerate immune cells.
- In a study comparing mice with different aging phenotypes, researchers found that certain stem cells in early aging mice showed increased aging-related gene activity, while those in delayed aging mice had genes helping with regulation and external responses.
- The shifts in blood cell lineage biases among hematopoietic stem cells (HSCs) reveal that targeting specific HSC subsets could be key in developing strategies to delay aging and improve immune function.
Article Synopsis
- Individual hematopoietic stem cells (HSCs) show variability in the amount of blood cells they produce when transplanted, prompting research into the link between gene expression and blood production.
- The study identified four distinct patterns in how genes correlate with blood production levels, with some genes having consistent effects while others peak at specific production levels.
- Findings suggest that certain genes regulate lymphoid production without influencing myeloid production, revealing complex molecular mechanisms behind blood cell generation in HSCs.
Many acute and chronic diseases affect the distal lung alveoli. Alveolar epithelial cell (AEC) lines are needed to better model these diseases. We used de-identified human remnant transplant lungs to develop a method to establish AEC lines.
View Article and Find Full Text PDFIn most organ systems, regeneration is a coordinated effort that involves many stem cells, but little is known about whether and how individual stem cells compensate for the differentiation deficiencies of other stem cells. Functional compensation is critically important during disease progression and treatment. Here, we show how individual hematopoietic stem cell (HSC) clones heterogeneously compensate for the lymphopoietic deficiencies of other HSCs in a mouse.
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- HPgV NS3 protease has been found to inhibit HIV replication in CD4+ T cells while also being similar to the HCV NS3 protease.
- Researchers investigated whether HPgV protease affects type I interferon responses or is impacted by HCV protease inhibitors and found that major HCV inhibitors do not affect HPgV activity.
- The study revealed that HPgV NS3 protease can cleave MAVS and inhibit interferon responses, potentially promoting HPgV persistence, which may provide clinical benefits for HIV-infected patients.
Background: The rd1 mouse retina is a well-studied model of retinal degeneration where rod photoreceptors undergo cell death beginning at postnatal day (P) 10 until P21. This period coincides with photoreceptor terminal differentiation in a normal retina. We have used the rd1 retina as a model to investigate early molecular defects in developing rod photoreceptors prior to the onset of degeneration.
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