HLA class I alleles frequencies in the Syrian population.

Objective: The HLA system is known to be the most polymorphic genetic loci in humans. Distribution and frequencies of HLA alleles are highly variable among different human ethnic groups. The HLA system has an important role in disease susceptibility and resistance, especially in autoimmune diseases and cancer.

Whole-body γ-irradiation decelerates rat hepatocyte polyploidization.

Purpose: To characterize hepatocyte polyploidization induced by intermediate dose of γ-ray.

Materials And Methods: Male Wistar strain rats were whole-body irradiated (WBI) with 2 Gy of γ-ray at the age of 1 month, and 5-6 rats were sacrificed monthly at 0-25 months after irradiation. The nuclear DNA content of individual hepatocytes was measured by flow cytometry, then hepatocytes were classified into various ploidy classes.