Publications by authors named "Adnan Labedi"
Background: In patients with embolic stroke of undetermined source (ESUS), underlying subclinical atrial fibrillation (AF) is often suspected. Previous studies identifying predictors of AF have been limited in their ability to diagnose episodes of AF. Implantable loop recorders enable prolonged, continuous, and therefore more reliable detection of AF.
View Article and Find Full Text PDFWe present a case of a 67-year-old female patient, who presented with acute cortical blindness five days after a successful resuscitation from cardiac arrest. The magnetic resonance tomography revealed a mild FLAIR signal increase of the bilateral occipital cortex. A lumbar puncture revealed considerably elevated tau protein levels, in the presence of normal phospho-tau, as a marker of brain injury, whilst neuron-specific enolase levels were normal.
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- Recent studies have identified inflammatory neuropathies that involve the nodes of Ranvier and are caused by specific autoantibodies, particularly anti-pan-NF-associated neuropathies, which are rare and can be life-threatening.
- A case of a 52-year-old male with this condition showed rapid progression to a severe "locked-in" syndrome, despite initial treatment, and was characterized by specific antibody presence and non-excitable nerves.
- A combination of aggressive immunotherapy, including rituximab and bortezomib, led to significant clinical improvement and normalization of nerve function over three months, suggesting this combination may be an effective treatment for these rare neuropathies.*
Background And Purpose: The ongoing Coronavirus Disease 2019 (COVID-19) pandemic is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is occasionally associated with manifold diseases of the central nervous system (CNS). We sought to present the neuroimaging features of such CNS involvement.
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- An 81-year-old woman was treated in the ICU for a serious poisoning from digitoxin, which is a type of medicine that can be very dangerous if too much is taken.
- Doctors used a special treatment called CytoSorb hemoadsorption along with kidney support to help her get better, which worked really well.
- After a few days, her digitoxin levels dropped to normal, and she was stable enough to leave the ICU, showing that CytoSorb could be a good option for treating this kind of poisoning.
Background: One of the main goals of novel, noninvasive imaging techniques like high-resolution nerve ultrasound (HRUS) and corneal confocal microscopy (CCM) is the prediction of treatment response for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
Methods: A total of 17 patients with CIDP were examined prospectively at baseline and every 9 months over a period of 18 months using CCM to quantify corneal nerve degeneration markers and immune cell infiltration as well as HRUS to detect changes of the cross-sectional area (CSA) of the peripheral nerves. Additionally, skin biopsy of the distal and proximal leg as well as quantitative sensory testing were performed at the first follow-up visit.
Introduction: We describe the nerve ultrasound findings in patients with type II diabetes mellitus who have neuropathic symptoms and signs.
Methods: Fifty-five healthy controls and 44 diabetic patients underwent clinical, sonographic, and electrophysiological evaluation. Patients were studied at a mean of 14.
Background: Intermittent theta-burst stimulation (iTBS) applied via transcranial magnetic stimulation has been shown to increase cortical excitability in humans. In the rat brain it strongly reduced the number of neurons expressing the 67-kD isoform of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD67) and those expressing the calcium-binding proteins parvalbumin (PV) and calbindin (CB), specific markers of fast-spiking (FS) and non-FS inhibitory interneurons, respectively, an indication of modified cortical inhibition.
Objective: Since iTBS effects in humans have been shown to be NMDA receptor sensitive, we wondered whether the iTBS-induced changes in the molecular phenotype of interneurons may be also sensitive to glutamatergic synaptic transmission mediated by NMDA receptors.