Differential Impact of Anxious Misery Psychopathology on Multiple Representations of the Functional Connectome.

Background: One aim of characterizing dimensional psychopathology is associating different domains of affective dysfunction with brain circuitry. The functional connectome, as measured by functional magnetic resonance imaging, can be modeled and associated with psychopathology through multiple methods; some methods assess univariate relationships while others summarize broad patterns of activity. It remains unclear whether different dimensions of psychopathology require different representations of the connectome to generate reproducible associations.

Cloud-Based Functional Magnetic Resonance Imaging Neurofeedback to Reduce the Negative Attentional Bias in Depression: A Proof-of-Concept Study.

Individuals with depression show an attentional bias toward negatively valenced stimuli and thoughts. In this proof-of-concept study, we present a novel closed-loop neurofeedback procedure intended to remediate this bias. Internal attentional states were detected in real time by applying machine learning techniques to functional magnetic resonance imaging data on a cloud server; these attentional states were externalized using a visual stimulus that the participant could learn to control.

Integration of memory content in adults and children: Developmental differences in task conditions and functional consequences.

How separate yet related episodes of experience are associated in memory is a major question in cognitive science and cognitive neuroscience. Adults and children both integrate content acquired in separate episodes, yet they may do so under different task conditions. Neuroimaging studies suggest that adults integrate the contents of separate memory traces at encoding and thus without an explicit prompt; behavioral studies suggest that children do so only when specifically prompted.