Publications by authors named "Adlane Ould-yahoui"
Adult olfactory ectomesenchymal stem cells (OE-MSCs) and olfactory ensheathing cells (OECs), both from the nasal olfactory lamina propria, display robust regenerative properties when transplanted into the nervous system, but the mechanisms supporting such therapeutic effects remain unknown. Matrix metalloproteinases (MMPs) are an important family of proteinases contributing to cell motility and axonal outgrowth across the extracellular matrix (ECM) in physiological and pathological conditions. In this study, we have characterized for the first time in nasal human OE-MSCs the expression profile of some MMPs currently associated with cell migration and invasiveness.
View Article and Find Full Text PDFOlfactory ensheathing cells (OECs) are unique glia found only in the olfactory system. They retain exceptional plasticity and support olfactory neurogenesis and retargeting across the PNS:CNS boundary in the olfactory system. OECs have been shown to improve functional outcome when transplanted into rodents with spinal cord injury.
View Article and Find Full Text PDFMatrix metalloproteinases (MMPs) are endopeptidases that cleave matrix, soluble and membrane-bound proteins and are regulated by their endogenous inhibitors the tissue inhibitors of MMPs (TIMPs). MMP-2 and MMP-9 are two of the MMPs which are essential to contribute to inflammatory and degenerative processes in injured nerves. The aim of the present study was to examine expression and activities of MMP-2 and MMP-9 in the injured and control groups frog sciatic nerves using gelatin zymography.
View Article and Find Full Text PDFArticle Synopsis
- TIMP-1 has diverse functions in the brain, particularly increasing in reactive astrocytes and neurons after injury or inflammation, but its specific effects on neuron growth and shape were previously unclear.
- After 24 hours of treatment, TIMP-1 notably decreased neurite length by 35%, while causing growth cones to enlarge and increasing the number of microprocesses, with effects lasting up to 48 hours.
- The changes induced by TIMP-1 do not stem from its ability to inhibit certain MMPs but may involve interactions with MMP-2, suggesting its role as a significant modulator of neuron morphology and growth in the context of brain injuries.
Astrocytes play an active role in the central nervous system and are critically involved in astrogliosis, a homotypic response of these cells to disease, injury, and associated neuroinflammation. Among the numerous molecules involved in these processes are the matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, secreted or membrane-bound, that regulate by proteolytic cleavage the extracellular matrix, cytokines, chemokines, cell adhesion molecules, and plasma membrane receptors. MMP activity is tightly regulated by the tissue inhibitors of MMPs (TIMPs), a family of secreted multifunctional proteins.
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- Matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) are involved in protein cleavage and are secreted from neuronal cells via specific vesicles, contributing to cellular processes.
- The study focuses on MMP-2, MMP-9, and TIMP-1, using advanced imaging techniques to reveal that they are secreted in vesicles that travel along microtubules and microfilaments.
- Findings indicate that these MMPs are localized in dendritic spines of neurons, highlighting their potential role in neuronal and synaptic plasticity.