Publications by authors named "Adiyantara Gumilang"
Article Synopsis
- 53 isolates of Aspergillus section Nidulantes fungi were studied, revealing that 30 clinical isolates, including four from COVID-19 patients, were misidentified as the cryptic pathogen A. latus, which resulted from a hybridization event.
- The research showed that A. latus displays significant genetic diversity and that both parental subgenomes are actively expressed in clinical isolates, responding to different environmental conditions.
- Key differences in drug resistance and growth in oxidative stress were found between A. latus hybrids and related species, along with four features that could help in accurately identifying A. latus in the future.
Article Synopsis
- Fungal pathogens like Aspergillus fumeigatus show strain variation in their ability to cause disease, but it's unclear if non-pathogenic relatives like Aspergillus fischeri do as well.
- This study analyzed 16 strains of A. fischeri and found significant differences in their potential to cause harm, supported by immune response tests and mouse models.
- Additionally, genomic analyses revealed that these strains have greater genetic diversity, with specific metabolites linked to their varying levels of virulence, highlighting the importance of studying closely related non-pathogenic species to understand fungal pathogenicity.
Article Synopsis
- Aspergillus fumigatus causes the infection known as aspergillosis and uses asexual spores to infect hosts, but little is known about how it evades the immune system.
- In this study, researchers analyzed the conidial surface proteins of A. fumigatus and compared them to two non-pathogenic species, discovering 62 proteins unique to A. fumigatus.
- Testing null mutants for 42 genes revealed that deleting 33 of these genes affected the fungus's ability to resist immune responses, particularly highlighting a gene that influences the proinflammatory cytokine IL-1β, which is crucial for infection in a mouse model.
Article Synopsis
- * Researchers studied 16 strains of a non-pathogenic fungus related to a major pathogen to assess their potential to cause disease, using immune response tests and a mouse model, revealing considerable variation in their pathogenic capabilities.
- * Further analyses, including genomic and metabolomic studies, indicated that the virulence of these strains may be influenced by specific secondary metabolites, suggesting that understanding these non-pathogenic relatives could shed light on the development of fungal pathogenicity.
Autophagy serves as a survival mechanism and plays important role in nutrient recycling under conditions of starvation, nutrient storage, ad differentiation of plant pathogenic fungi. However, autophagy-related genes have not been investigated in , a causal agent of pepper fruit anthracnose disease. is involved in autophagosome formation and is considered a marker of autophagy.
View Article and Find Full Text PDFRice blast disease, caused by the ascomycete fungus , is one of the most important diseases in rice production. PAS (period circadian protein, aryl hydrocarbon receptor nuclear translocator protein, single-minded protein) domains are known to be involved in signal transduction pathways, but their functional roles have not been well studied in fungi. In this study, targeted gene deletion was carried out to investigate the functional roles of the PAS-containing gene (MGG_02665) in .
View Article and Find Full Text PDFThe rice blast pathogen is a global threat to rice production. Here we characterized gene () that belongs to the Rho GTPase family, using a deletion mutant. This mutant exhibited no defects in conidiation and germination but developed only 6% of appressoria in response to a hydrophobic surface when compared to the wild-type progenitor.
View Article and Find Full Text PDFis a necrotrophic pathogen causing a major problem in the export and post-harvest of strawberries. Inappropriate use of fungicides leads to resistance among fungal pathogens. Therefore, it is necessary to evaluate the sensitivity of to various classes of fungicide and to determine the effectiveness of different concentrations of commonly used fungicides.
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