Publications by authors named "Aditya Parthasarathy"
The brush border is comprised of microvilli surface protrusions on the apical surface of epithelia. This specialized structure greatly increases absorptive surface area and plays crucial roles in human health. However, transcriptional regulatory networks controlling brush border genes are not fully understood.
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- The study explores how transcription factors HNF4A and HNF4G regulate metabolism and the functioning of intestinal stem cells (ISCs) in mice.
- The researchers used specific transgenic mouse lines to analyze the impact of fatty acid absorption and metabolism on the expression of stem cell markers.
- They found that fatty acid oxidation (FAO) is crucial for ISC renewal, and while individually knocking out HNF4A or HNF4G didn't affect ISCs, their combined knockout led to significant declines in ISC function.
As embryos mature, cells undergo remarkable transitions that are accompanied by shifts in transcription factor regulatory networks. Mechanisms driving developmental transitions are incompletely understood. The embryonic intestine transitions from a rapidly proliferating tube with pseudostratified epithelium prior to murine embryonic day (E) 14.
View Article and Find Full Text PDFBMP/SMAD signaling is a crucial regulator of intestinal differentiation. However, the molecular underpinnings of the BMP pathway in this context are unknown. Here, we characterize the mechanism by which BMP/SMAD signaling drives enterocyte differentiation.
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