Precise NMR Method for Titering Organometal Reagents.

The concentration of organometal reagents can be conveniently determined by obtaining the NMR spectra of the neat reagent solution, and, in a second NMR tube, of a neat reference solvent. The PULCON relationship, implemented in all major NMR software, is then used to calculate the concentration of the reagent based on the absolute integrals in the spectra, the known concentration of the reference, and the number of protons under the integrals.