Publications by authors named "Aditya Katewa"
Article Synopsis
- Choline is a crucial nutrient needed by the body for processes like building cell membranes and neurotransmission, with the brain having the highest demand for it.
- The protein FLVCR2, found in cells at the blood-brain barrier, is identified as the main transporter for choline into the brain, unlike another related protein, FLVCR1, which is not as active there.
- Research includes structural analysis of FLVCR2 using cryo-electron microscopy, which shows how choline binds and is transported, offering potential insights for delivering therapies into the brain more effectively.
Microglia diversity emerges from interactions between intrinsic genetic programs and environment-derived signals, but how these processes unfold and interact in the developing brain remains unclear. Here, we show that radial glia-expressed integrin beta 8 (ITGB8) expressed in radial glia progenitors activates microglia-expressed TGFβ1, permitting microglial development. Domain-restricted deletion of in these progenitors establishes complementary regions with developmentally arrested "dysmature" microglia that persist into adulthood.
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- Alzheimer's disease (AD) is a major cause of dementia and is characterized by the buildup of toxic proteins like amyloid beta (Aβ), which trigger harmful neuroinflammation.
- A study tested gedunin, an anti-inflammatory compound from neem tree seeds, showing it can reduce neuroinflammation caused by Aβ exposure in mouse microglia.
- Gedunin works by inhibiting the activation of inflammatory pathways and enhancing protective responses, suggesting it could be a promising treatment for neurodegenerative diseases.