Evaluating implementation of NCCN guideline-directed genetic screening recommendations for patients with pancreatic ductal adenocarcinoma.

Purpose: In 2019, the National Comprehensive Cancer Network (NCCN) recommended genetic testing for all patients with pancreatic ductal adenocarcinoma (PDAC). To evaluate the status of implementation of these guidelines in a loco-regional setting, we performed a retrospective, observational study among patients with newly diagnosed PDAC who received oncologic care at Northeast Georgia Medical Center in Georgia.

Methods: Chart abstraction of patients with newly diagnosed PDAC from 1 January 2020 to 31 December 2021 was performed to include information on genetic testing recommendation and completion, and time from diagnosis to testing.

The Female-Predominant Persistent Immune Dysregulation of the Post-COVID Syndrome.

Objective: To describe the clinical data from the first 108 patients seen in the Mayo Clinic post-COVID-19 care clinic (PCOCC).

Methods: After Institutional Review Board approval, we reviewed the charts of the first 108 patients seen between January 19, 2021, and April 29, 2021, in the PCOCC and abstracted from the electronic medical record into a standardized database to facilitate analysis. Patients were grouped into phenotypes by expert review.

Anti-Spike Monoclonal Antibody Therapy in Pregnant Women With Mild-to-Moderate Coronavirus Disease 2019 (COVID-19).

Anti-spike monoclonal antibody therapy may be effective for pregnant women with coronavirus disease 2019 (COVID-19).

Falling "fortresses": Unlocking Governance Entanglements and Shifting Knowledge Paradigms to Counter Climate Change Threats in Biodiversity Conservation.

Biodiversity conservation is facing unprecedented challenges at the intersection of rapidly changing climates, widespread ecosystem degradation under the influence of global warming and resultant human tragedies over livelihood, habitation, adaptation and coping needs. These challenges are more acute across biodiversity hotspots in the Global South. This study disentangles the complex interplay to propose alternative paradigms of governance and policy thinking necessary for sustainable biodiversity conservation.

PROMIS Scales for Assessment of Persistent Post-COVID Symptoms: A Cross Sectional Study.

Objective: Persistent post-COVID symptoms are estimated to occur in up to 10% of patients who have had COVID-19. These lingering symptoms may persist for weeks to months after resolution of the acute illness. This study aimed to add insight into our understanding of certain post-acute conditions and clinical findings.

Effective Patient-Physician Communication - A Concise Review.

Current medical care is heavily reliant on the use of evidence-based guidelines dealing with diagnosis and therapy. The burgeoning medical literature, easy availability of medical information in the social media and consumerism has increased the additional number of issues discussed during a patient physician meeting. Inability to satisfy the patient or their families due to poor communication skills of physicians remains an universal challenge all over the world.

Communication Adaptations for a Diverse International Patient Population.

We live in an age of hyper connectivity, people from around the world are looking outside their own national borders to receive medical care. As more people are learning about the quality that the elite Indian hospitals provide at a competitive, and often more affordable, price compared to other institutions around the world, they are becoming increasingly interested in receiving their medical care in Indian hospitals. It is for this exact reason that it is very important to learn the importance of communicating effectively with people from a diverse background.

Hand Massage for Cancer Patients Undergoing Chemotherapy as Outpatients: A Pilot Study.

Context: There are no studies on the effect of volunteer-provided hand massage in a busy chemotherapy outpatient practice.

Objective: To assess the feasibility of introducing hand massage therapy into an outpatient chemotherapy unit and to evaluate the effect of the therapy on various symptoms experienced by cancer patients.

Design: A pilot, quasi-experimental, pretest-posttest study.

Concordance of changes in metabolic pathways based on plasma metabolomics and skeletal muscle transcriptomics in type 1 diabetes.

Insulin regulates many cellular processes, but the full impact of insulin deficiency on cellular functions remains to be defined. Applying a mass spectrometry-based nontargeted metabolomics approach, we report here alterations of 330 plasma metabolites representing 33 metabolic pathways during an 8-h insulin deprivation in type 1 diabetic individuals. These pathways included those known to be affected by insulin such as glucose, amino acid and lipid metabolism, Krebs cycle, and immune responses and those hitherto unknown to be altered including prostaglandin, arachidonic acid, leukotrienes, neurotransmitters, nucleotides, and anti-inflammatory responses.