Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia.

Unlabelled: Macroautophagy (autophagy hereafter) captures intracellular components and delivers them to lysosomes for degradation and recycling . In adult mice, autophagy sustains metabolism to prevent wasting by cachexia and to survive fasting, and also suppresses inflammation, liver steatosis, neurodegeneration, and lethality . Defects in autophagy contribute to metabolic, inflammatory and degenerative diseases, however, the specific mechanisms involved were unclear .