Publications by authors named "Aditi Singhania"
Article Synopsis
- Proprioceptors are crucial for sensing body position and enabling coordinated movement, but how animals with flexible skeletons encode their body positions is not well understood.
- In this study, researchers used advanced SCAPE microscopy to observe the activity of proprioceptors in crawling Drosophila larvae, revealing that most neurons activated during segment contraction, while one subtype responded to extension.
- The findings highlight the sequential activation of different proprioceptor types during movement, suggesting they play distinct roles in monitoring body deformation, and demonstrate the effectiveness of SCAPE microscopy for exploring neural activity in live animals.
Development of the embryonic and larval peripheral nervous system of Drosophila.
Wiley Interdiscip Rev Dev Biol
January 2015
Article Synopsis
- The PNS in embryonic and larval Drosophila is made up of various sensory neurons that have consistent locations and shapes, making it an ideal system for studying neural development.
- Research on Drosophila's PNS has revealed important mechanisms of how sensory neurons are formed, how they divide asymmetrically, and how their dendrites develop, influenced by several factors.
- The axons of sensory neurons exhibit specific termination patterns in the central nervous system, guided by signaling molecules, which are essential for the organism's coordinated movements and behaviors.
Transcriptional enhancers are a primary mechanism by which tissue-specific gene expression is achieved. Despite the importance of these regulatory elements in development, responses to environmental stresses and disease, testing enhancer activity in animals remains tedious, with a minority of enhancers having been characterized. Here we describe 'enhancer-FACS-seq' (eFS) for highly parallel identification of active, tissue-specific enhancers in Drosophila melanogaster embryos.
View Article and Find Full Text PDFA subfamily of Drosophila homeodomain (HD) transcription factors (TFs) controls the identities of individual muscle founder cells (FCs). However, the molecular mechanisms by which these TFs generate unique FC genetic programs remain unknown. To investigate this problem, we first applied genome-wide mRNA expression profiling to identify genes that are activated or repressed by the muscle HD TFs Slouch (Slou) and Muscle segment homeobox (Msh).
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