surfaltr: An R/Bioconductor package to benchmark surface protein isoforms by rapid prediction and visualization of transmembrane topologies.

Cell surface proteins form a major fraction of the druggable proteome and can be used for tissue-specific delivery of oligonucleotide/cell-based therapeutics. Surface protein isoforms are regulated by alternative splicing, which drives subcellular localization and transmembrane (TM) topology thereby shaping cell type specific signatures. Current advances in multiomic approaches have developed interest in discovery of tissue-specific alternatively spliced or novel surface protein isoforms.

: A Promising Intergenerational Program for Social Connections.

Introduction: To help older adults cope with loneliness during COVID-19, a weekly, telephone-based intergenerational program called "" was created in April 2020 to link young and older adults together. As part of an evaluation of , a survey with both close and open-ended questions was sent to participants.

Methods: A total of 63 Bigs and 53 Minis completed the survey.