Publications by authors named "Adithya Jayaprakash Kamath"

Curcumin, a well-known bioactive component, has profound effects against colon cancer. However, the limitations are poor systemic absorption, off-target distribution, chemical instability, short half-life, and less concentration reaching tumor tissues. Several drug delivery systems have been evaluated so far to deliver effective concentrations of curcumin to the malignant tissues.

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Article Synopsis
  • Metabolic dysfunction-associated steatohepatitis (MASH) and its progression to hepatocellular carcinoma (HCC) are influenced by unique molecular and immune features, especially connected to the gut microbiome.
  • The "gut-liver axis" reflects the crucial interaction between the gut microbiota and the liver, impacting the development and disease progression through microbial metabolites and immune responses.
  • A literature review from various databases highlights the gut microbiota's significant role in MASH and HCC, calling for more clinical research to improve diagnostic methods and create targeted therapies to help treat liver diseases.
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The Hedgehog (Hh) signaling plays a crucial role in adult liver repair by promoting the expansion and differentiation of hepatic progenitor cells into mature hepatocytes and cholangiocytes. Elevated Hh signaling is associated with severe chronic liver diseases, making Hh inhibitors a promising therapeutic option. Sonidegib and vismodegib, both FDA-approved Smoothened (Smo) inhibitors for basal cell carcinoma (BCC), have shown potential for application in chronic liver disorders based on clinical evidence.

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The role of mast cells, traditionally recognized for their involvement in immediate hypersensitivity reactions, has garnered significant attention in liver diseases. Studies have indicated a notable increase in mast cell counts following hepatic injury, underscoring their potential contribution to liver disorder pathogenesis. Predominantly situated in connective tissue that envelops the hepatic veins, bile ducts, and arteries, mast cells are central to both initiating and perpetuating liver disorders.

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Embelin, a natural para-benzoquinone product, is derived from plants of the Embelia genus, particularly Burm.f. A staple in traditional medicinal formulations for centuries, Embelin's pharmacological actions are attributed to the hydroxyl benzoquinone present in its structure.

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