Publications by authors named "Adinarayana Bellamkonda"
The discovery of new compounds with pharmacological properties is usually a lengthy, laborious and expensive process. Thus, there is increasing interest in developing workflows that allow for the rapid synthesis and evaluation of libraries of compounds with the aim of identifying leads for further drug development. Herein, we apply combinatorial synthesis to build a library of 90 iridium(III) complexes (81 of which are new) over two synthesise-and-test cycles, with the aim of identifying potential agents for photodynamic therapy.
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- A tetrahedral FeL cage forms by coordinating triangular chiral ligands to iron(II), leading to two diastereomers that differ in metal vertex stereochemistry while having the same ligand chirality.
- The equilibrium of these diastereomers is affected by the binding of guest molecules, which is determined by the size and shape fit of the guest within the cage.
- Atomistic simulations helped clarify how stereochemistry impacts guest binding, allowing for the development of a simple method to separate the enantiomers of a racemic guest.
Stable B -subporphyrin-substituted dicyanomethyl radicals were synthesized by S Ar reaction of meso-bromo- or meso-chlorosubporphyrins with malononitrile followed by oxidation with PbO . Different from previously reported dicyanomethyl radicals that underwent σ- or π-dimer formation both in the solid state and in solutions, subporphyrin-stabilized dicyanomethyl radicals exist as monomers in solutions even at low temperature. DFT calculations revealed efficient spin delocalization over the entire subporphyrin.
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