Zingerone mitigates metabolic dysfunction and alters pro-opiomelanocortin gene expression in offspring of high-fat diet-fed pregnant wistar rats.

Objectives: , exposure to maternal high-fat diet (HFD) has been identified to predispose the offspring to obesity and other metabolic dysfunctions later in life. Zingerone, a bioactive phytochemical found in ginger has potential for the treatment of metabolic diseases due to its antioxidant properties. This study investigated its potential reprogramming effect on some metabolic indices and pro-opiomelanocortin (POMC) gene in young adult offspring of Wistar rat models exposed to maternal HFD.

Concomitant Administration of Aloe Vera Gel and Rifampicin Protects Against Rifampicin Hepatorenal Toxicity in Male Wistar Rats.

Background: Rifampicin, an antibiotic used in the treatment of tuberculosis has raised concerns about its potential liver and kidney toxicity.

Aim: This study aimed to evaluate the protective effects of Aloe vera against hepatorenal toxicity induced by rifampicin in male Wistar rats.

Methods: Thirty rats were divided into six groups (n = 5): group A (control), group B treated with rifampicin, groups C-E treated with varying doses (50, 100, and 200 mg/kg) of Aloe vera alongside rifampicin as well as a group F treated with furosemide and rifampicin for a total of 30 days.

Capecitabine and sixth cranial nerve palsy.

Capecitabine is an oral chemotherapeutic agent converted to 5 fluorouracil (5-FU). Neurotoxicity associated with the medication encompasses both central and peripheral nervous systems. We describe a 60 year old man with colonic carcinoma who developed diplopia due to a sixth nerve palsy following the use of capecitabine which is an orally administered prodrug of 5-FU.