Abnormalities in gut virome signatures linked with cognitive impairment in older adults.

Multiple emerging lines of evidence indicate that the microbiome contributes to aging and cognitive health. However, the roles of distinct microbial components, such as viruses (virome) and their interactions with bacteria (bacteriome), as well as their metabolic pathways (metabolome) in relation to aging and cognitive function, remain poorly understood. Here, we present proof-of-concept results from a pilot study using datasets ( = 176) from the Microbiome in Aging Gut and Brain (MiaGB) consortium, demonstrating that the human virome signature significantly differs across the aging continuum (60s vs.

CHRONIC DIARRHOEA: NOT A RARE PRESENTATION OF VITAMIN B 12 DEFICIENCY.

Background: Diarrhoea is defined as stool frequency of more than three times in twenty-four hours or a stool weight of more than two hundred grams and it is labelled as chronic diarrhoea if it persists for more than four weeks. Chronic diarrhoea is a common gastrointestinal problem worldwide that affects three to fifteen percent of population. Objective was to determine the efficacy of vitamin B 12 replacement in treatment of chronic diarrhoea in vitamin B deficient patients.

Toxic elements identified in breast milk of mothers residing in water contaminated region of Sindh and their impact on infants' growth patterns: A case-control study.

Breast milk is a vital source of nutrition for breastfed infants, providing essential nutrients and elements but, in some cases, toxic ones. This is the first case-control study that investigated the elemental profile of breast milk samples collected from mothers residing in Matiari (Sindh), a region with insufficient industrial waste management, and its potential impact on infants' anthropometrics. Precisely, 62 milk samples, including 42 cases and 20 controls, were analyzed using the ICP-MS technique.

Cross-Cultural Adaptation of Mediterranean Diet Adherence Screener (MEDAS) Into Moroccan Arabic to Measure the Degree of Mediterranean Diet Adherence.

Background The Mediterranean diet (MD) has been recognized by several studies as beneficial for health improvement. The degree of adherence to this diet has also been evaluated using several scales, particularly time-consuming measures such as the Food Frequency Questionnaire (FFQ). This study aims to (a) adapt into Moroccan Arabic the 14-item Mediterranean Diet Adherence Screener (MEDAS), which is a simple and brief tool that assesses the degree of diet adherence and was used in the Prevencion con Dieta Mediterranea (PREDIMED) study, and (b) determine its psychometric properties.

Self-Calibrated Ion-Selective Electrodes.

Ion-selective electrode (ISE) potentiometry is reliable only if on-site calibration using a standard solution is performed before ion measurements. The complex device and operation required for calibration hinder the implementation of ISEs in decentralized sensing. Reported herein is a new type of ISE that is calibrated by a built-in component of the sensor without requiring any fluid handling processes.

Coseismic Deformation Field and Fault Slip Distribution Inversion of the 2020 Jiashi 6.4 Earthquake: Considering the Atmospheric Effect with Sentinel-1 Data Interferometry.

Due to some limitations associated with the atmospheric residual phase in Sentinel-1 data interferometry during the Jiashi earthquake, the detailed spatial distribution of the line-of-sight (LOS) surface deformation field is still not fully understood. This study, therefore, proposes an inversion method of coseismic deformation field and fault slip distribution, taking atmospheric effect into account to address this issue. First, an improved inverse distance weighted (IDW) interpolation tropospheric decomposition model is utilised to accurately estimate the turbulence component in tropospheric delay.

Metabolomics Study of Serum Samples of β-YAC Transgenic Mice Treated with Tenofovir Disoproxil Fumarate.

β-thalassemia is one of the most common monogenic disorders and a life-threatening health issue in children. A cost-effective and safe therapeutic approach to treat this disease is to reactivate the γ-globin gene for fetal hemoglobin (HbF) production that has been silenced during infancy. Hydroxyurea (HU) is the only FDA approved HbF inducer.

Numerical Study on an RBF-FD Tangent Plane Based Method for Convection-Diffusion Equations on Anisotropic Evolving Surfaces.

In this paper, we present a fully Lagrangian method based on the radial basis function (RBF) finite difference (FD) method for solving convection-diffusion partial differential equations (PDEs) on evolving surfaces. Surface differential operators are discretized by the tangent plane approach using Gaussian RBFs augmented with two-dimensional (2D) polynomials. The main advantage of our method is the simplicity of calculating differentiation weights.

What would be the impact of COVID-19 on liver function of a patient with chronic hepatitis B? About a case and literature review.

Liver damage during COVID-19 disease has been described in numerous studies. Its mechanism is poorly understood. It is mainly reserved for severe forms and is manifested by abnormalities of the hepatic assessment and more particularly cytolysis.

Evaluation of cytotoxicity of areca nut and its commercial products on normal human gingival fibroblast and oral squamous cell carcinoma cell lines.

Consumption of areca nut products is the most common cause of oral cancers, particularly in South Asian countries. This study evaluates the cytotoxic and necrotizing effects of areca nut and its formulations on normal human gingival fibroblasts (HGF-1) and oral squamous cell carcinoma (OSCC, CAL-27) cell lines. Identification of various carcinogens and adulterants using LC-HR-ESI-MS/MS analysis was performed in the extracts of areca nut and its products.

Compatibility and stability of polygeline (Haemaccel) with different drug products.

Compatibility and stability of the polygeline-based blood plasma expander/plasma substitute Haemaccel with different drug products i.e., Profenid, Stemetil, and Lasix were examined in the context of its potential use in surgical, spinal, septic shock and in circulatory insufficiency, because treatment, safety, acceptability and efficacy of drug product may be affected by drug instability or incompatibility.

Stability Studies of Two Different Polygelin (Haemaccel and Gelofusine) According to ICH Guidelines.

Unlabelled: The stability of polygeline-based blood plasma expanders Haemaccel and Gelofusine were examined in context of their sensitivity to environmental factors, because drug stability is critical element in accurate and appropriate delivery of drug therapy to patients. This study was initiated to specifically and critically assess stability of Haemaccel and Gelofusine according to ICH guidelines with the aim of delivering safe, appropriate, acceptable, and efficacious administration of drug product in any situation. This study revealed that Haemaccel and Gelofusine are suitable for storage at different temperature and at different storage conditions until its expiry date, shelf life, or utility time, for their quality, safety, suitability, acceptability, and efficacy.

Delayed replantation of avulsed teeth.

Dental injuries are very common and their extent has been classified by Ellis. Avulsion of tooth is a grievous injury and ranges from 1-16% among the traumatic injuries, of which maxillary anterior are commonest. Reimplantation of avulsed teeth is a standard procedure.

Intraspecific variability and pharmacokinetic characteristics of Androctonus mauretanicus mauretanicus scorpion venom.

We evaluated the degree of venom toxicity and protein content of several specimens of Androctonus mauretanicus mauretanicus. The quantity of protein of individual venom obtained after manual extraction from 31 different scorpions varied from a minimum of 0.15 mg to a maximum of 1.