Phoenixin (PNX) is a neuropeptide that significantly influences metabolism and reproduction, playing a role in energy homeostasis, glucose, lipid metabolism, and mitochondrial function.
PNX is primarily found in the hypothalamus and is involved in reproductive hormone regulation, as well as being present in other tissues like the heart and pancreas, indicating its widespread metabolic control.
The peptide acts through G protein-coupled receptor 173 (GPR173) and may have therapeutic potential for managing conditions like obesity, type 2 diabetes, and infertility, making further research crucial for developing treatment strategies.