Publications by authors named "Adi Soffer"
Article Synopsis
- Autism spectrum disorder (ASD) is associated with social and cognitive difficulties, and certain genetic mutations, particularly in the Shank3 gene, are linked to specific cases of monogenic ASD.
- Research using the InsG3680 mouse model shows that Shank3 plays an important role in the functioning of oligodendrocytes (cells that support myelin in the brain) and affects their development negatively when mutated.
- The study found that InsG3680 mice had significant issues with myelin formation and motor skills, showing that problems with Shank3 and oligodendrocytes may contribute to the neurological aspects of ASD.
Bioprinting technology offers unprecedented opportunities to construct in vitro tissue models that recapitulate the 3D morphology and functionality of native tissue. Yet, it remains difficult to obtain adequate functional readouts from such models. In particular, it is challenging to position sensors in desired locations within pre-fabricated 3D bioprinted structures.
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