In vitro evaluation of aspiration of hyaluronic acid filler with a new saline flashing method.

Aims: In vitro evaluation of aspiration of viscous hyaluronic acid (HA) fillers through dermatologic needles, with and without a new solution for safe aspiration with a saline flashing procedure. The final objective is to be able to offer an easy-to-use device for a practitioner who injects fillers under and into the skin blindly. This device aims to protect him from an immediate and reproducible intravascular venous or arterial injection whatever the type of product used and independently of its rheological properties or the diameter of the needle used.

Measurement of the time of flight of photons into the skin: influence of site, age and gender, correlation with other skin parameters.

Background/purpose: The speed of light (time of flight) into the skin is obviously relied to its structure, and might appear as a tool for non-invasive investigation of skin physico-chemical properties, among them aging is of primary importance. Though already published, such time of flight measurements have never been extensively correlated with other well-documented skin parameters such as localization, the influence of gender and age, the elasticity and roughness, and the water trans-epidermal diffusion (TEWL).

Methods: A specific practical device was designed to routinely measure the time of flight (TOF) of the light into the human skin 'in vivo', in a totally non-invasive process.

Randomized study of tolerance and efficacy of a home-use intense pulsed light (IPL) source compared to the hot-wax method.

Background: More and more we are seeing depilatory mechanisms based on IPL technology and used at home. As far as we know, these appliance have not undergone either safety or efficacy testing.

Aims: The aim of the study was to compare tolerance and efficacy of two depilation methods a medical device in-home-use IPL (E-One) and hot wax.

Efficacy and safety of 0.1% retinaldehyde/ 6% glycolic acid (diacneal) for mild to moderate acne vulgaris. A multicentre, double-blind, randomized, vehicle-controlled trial.

Background: Retinaldehyde and glycolic acid are both efficient in acne.

Objective: To evaluate the efficacy and tolerability of a 0.1% retinaldehyde/6% glycolic acid combination (Diacneal) for mild to moderate acne vulgaris.

Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids.

Background/aims: The ultraviolet (UV) portion of sunlight is involved in the induction and development of skin cancers against which a limited photoprotection may be provided by reduced time of exposure, clothing, and sunscreen applications. The concept of an effective, safe, systemic photoprotection will circumvent many of the shortcomings. The UV-induced oxidative stress is a cause of DNA damage and a few publications have shown, in humans, minimal benefits, if any, of the oral intake of antioxidant complex, contrasting with the large literature showing beneficial effects in vitro or in animal models.

Antiinflammatory properties of cetirizine in a human contact dermatitis model. Clinical evaluation of patch tests is not hampered by antihistamines.

The aim of this double-blind, placebo-controlled, randomized, cross-over pilot study was to assess the antiinflammatory properties of cetirizine. A group of 27 patients with a positive patch test to an allergen consecutively received cetirizine 10 mg o.d.

Chromametric quantification of pigmentary changes in the solar lentigo after sunlight exposure.

The purpose of this study is to compare by chromametric analysis the changes seen in normal skin and solar lentigos after exposure to sunlight. The color measurements were made with a Minolta CR200 chromameter and expressed in the L*a*b* system, which allows a color to be quantified according to 3 axes: white-black (L*), red-green (a*) and yellow-blue (b*). In order to better assess the sensitivity of physiological mechanisms involved in this pigmentation, we chose the weakest conditions of sunlight: the first series of measurements were made at the end of the winter (March) on areas rarely exposed for several months, and the second measurement was made 2 months later before the first intense summer solar exposure.

Influence of age and sun exposure on the biophysical properties of the human skin: an in vivo study.

The physical properties of the skin were measured by using noninvasive methods on 72 people displaying various levels of solar elastosis on the neck. The physical parameters measured were the skin extensibility, the elastic recovery, the skin colour, the skin thickness and the electrical conductance. The correlation between the above parameters, the clinical grades of elastosis and the chronological age of each subject were studied using two different statistical approaches.

[Development of non-cellular dermis: a step towards a total artificial skin].

In large cutaneous defects due to severe burns, dermal mesenchyme healing has to be controlled in order to avoid granulation tissue that rapidly leads to important contractures and hypertrophic scars. We report a study about the use of an artificial dermis made of human collagen (I and III) and several glycosaminoglycans. This artificial dermis was grafted on Sprague-Dawley rats after a 9 cm2 skin excision on the back.