Therapeutic potency of kaempferol against Naja haje venom induced neurotoxicity, inflammation, biological activities, and antioxidant system damage: a pre-clinical antivenom evaluation.

Naja haje envenoming manifests organ system disorders leading to severe fatalities due to the venom's toxins. The neutralizing capacity of kaempferol has been reported against some medically significant snake venoms with exception of N. haje venom (NhV).

Echis ocellatus venom-induced sperm functional deficits, pro-apoptotic and inflammatory activities in male reproductive organs in rats: antagonistic role of kaempferol.

Background: Echis ocellatus envenoming is potentially toxic initiating clinical damages on male reproductive system. Kaempferol is a therapeutic agent with neutralizing potentials on snake venom toxins. This study investigated the antagonistic effect of kaempferol on E.

Potassium permanganate-modified eggshell biosorbent for the removal of diclofenac from liquid environment: adsorption performance, isotherm, kinetic, and thermodynamic analyses.

This study assess how well diclofenac (DCF) can be separated from aqueous solution using potassium permanganate-modified eggshell biosorbent (MEB). The MEB produced was characterised using XRD, FTIR, and SEM. Batch experiments were conducted to examine and assess the impact of contact time, adsorbent dosage, initial concentration, and temperature on the adsorption capacity of the MEB in the DCF sequestration.

Dabsylated Bradykinin Is Cleaved by Snake Venom Proteases from .

The vasoactive peptide bradykinin (BK) is an important member of the renin-angiotensin system. Its discovery is tightly interwoven with snake venom research, because it was first detected in plasma following the addition of viper venom. While the fact that venoms liberate BK from a serum globulin fraction is well described, its destruction by the venom has largely gone unnoticed.

Kaempferol mitigates reproductive dysfunctions induced by Naja nigricollis venom through antioxidant system and anti-inflammatory response in male rats.

Naja nigricollis Venom (NnV) contains complex toxins that affects various vital systems functions after envenoming. The venom toxins have been reported to induce male reproductive disorders in envenomed rats. This present study explored the ameliorative potential of kaempferol on NnV-induced male reproductive toxicity.

Kaempferol from Moringa oleifera demonstrated potent antivenom activities via inhibition of metalloproteinase and attenuation of Bitis arietans venom-induced toxicities.

Bitis arietans venom (BAV) can induce severe pathophysiological disorders after envenoming. However, studies have shown that the Moringa oleifera fraction is effective against BAV toxicities and contains bioactive compounds with significant antivenom potency. This research aimed to identify the main active antivenom compound in the M.

Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats.

Dimethyl nitrosamine (DMN) is a known hepatotoxin, carcinogen, and mutagen. This study is therefore carried out to investigate the therapeutic effects of syringic acid (SYRA) and ascorbic acid (ASCA) in DMN-induced hepatic injury in rats. Following DMN administrations, malondialdehyde (MDA), nitric oxide (NO) and reduced glutathione (GSH) as well as activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) were significantly increased.

Removal of Cationic Dyes by Iron Modified Silica/Polyurethane Composite: Kinetic, Isotherm and Thermodynamic Analyses, and Regeneration via Advanced Oxidation Process.

Emerging dye pollution from textile industrial effluents is becoming more challenging for researchers worldwide. The contamination of water by dye effluents affects the living organisms in an ecosystem. Methylene blue (MB) and malachite green (MG) are soluble dyes with a high colour intensity even at low concentration and are hazardous to living organisms.

Adaptive neuro fuzzy inference system modeling of Synsepalum dulcificum L. drying characteristics and sensitivity analysis of the drying factors.

The requirement for easily adoptable technology for fruit preservation in developing countries is paramount. This study investigated the effect of pre-treatment (warm water blanching time-3, 5 and 10 min at 60 °C) and drying temperature (50, 60 and 70 °C) on drying mechanisms of convectively dried Synsepalum dulcificum (miracle berry fruit-MBF) fruit. Refined Adaptive Neuro Fuzzy Inference System (ANFIS) was utilized to model the effect and establish the sensitivity of drying factors on the moisture ratio variability of MBF.

Venom-Induced Reproductive Pathologies in Rat Model; Roles of Oxidative Stress and Pro-Inflammatory Cytokines.

This study reported reproductive pathologies associated with Echis ocellatus venom in animal model. Twenty male Wistar rats with body weight between 180 and 220 g were selected randomly into two groups (n = 10). Rats in group 1 served as the control while rats in group 2 were envenomed with a single intraperitoneal injection of 0.

Efficient sequestration of boron from liquid phase by amidoxime-functionalized poly(acrylonitrile-co-acrylic acid): experimental and modelling analyses.

This study aims to produce amidoxime-modified poly(acrylonitrile-co-acrylic acid) using an optimized method and to investigate the performance of amidoxime-modified poly(acrylonitrile-co-acrylic acid) on the adsorption of boron ions in batch operations. Batch adsorption was conducted at the physiochemical parameters of pH, adsorbent dosage, and initial boron concentration. The isotherms and kinetics of adsorption data were studied at various initial boron concentrations.

venom altered reproductive and neurological functions via modulation of pro-inflammatory cytokines and oxidative damage in male rats.

Reproductive and neurological anomalies are often characterized by malfunctioning of reproductive and nervous organs sometimes attributed to systemic toxins. However, limited information is available on the impact of snake venom toxins on male reproductive and nervous system. This study investigated the toxicological effects of venom on male reproductive and neural functions in rat model.

Process optimization, scale-up studies, economic analysis and risk assessment of phenolic rich bioactive extracts production from L. leaves via heat-assisted extraction technology.

This work investigated the influence of process variables of extraction temperature (35-55 °C), solid to liquid ratio (1:20-1:50 g/mL) and time (100-200 min) on the total phenolic content (TPC) and yield (EY) of leaves (CPL) extracts using Box-Behnken experimental design available in Design Expert software. Bi-objective process optimization was also carried out using the desirability function algorithm. The optimum process variables were later used to design an integrated process for the production of CPL extracts with the assistance of SuperPro Designer software.

Extract Extenuates Venom-Induced Toxicities, Histopathological Impairments and Inflammation via Enhancement of Nrf2 Expression in Rats.

snakebite causes more fatalities than all other African snake species combined. reportedly possesses an antivenom property. Therefore, we evaluated the effectiveness of ethanol extract (MOE) against (EOV) toxicities.

Hot air convective drying of hog plum fruit (): effects of physical and edible-oil-aided chemical pretreatments on drying and quality characteristics.

This aim of this study was to evaluate the effects of pretreatments and temperature on the hot air drying characteristics of hog plum fruits. Hog plum fruits were pretreated with olive oil/KCO or sunflower oil/KCO at 28 °C and olive oil/NaOH cum blanching at 96 °C for 15s, hot water at 96 °C for 15s, and dried in a hot air drier at 50, 60, and 70 °C. Mathematical models were used to fit the data of drying and rehydration kinetics.

Sequestration of p-nitrophenol from liquid phase by poly(acrylonitrile-co-acrylic acid) containing thioamide group.

In this paper, the adsorptive performance of synthesized thiourea (TU) modified poly(acrylonitrile-co-acrylic acid) (TU-P(AN-co-AA)) polymeric adsorbent for capturing p-nitrophenol (PNP) from aqueous solution was investigated. TU-P(AN-co-AA) was synthesized via the redox polymerization method with acrylonitrile (AN) and acrylic acid (AA) as the monomers, then modified chemically with thiourea (TU). Characterization analysis with Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), elemental microanalysis for CHNS, zeta potential measurement, Brunauer-Emmett-Teller (BET) surface analysis and thermal analyses were carried out to determine the morphology and physico-chemical properties of the synthesized polymer.

Optimisation of microwave-assisted extraction and functional elucidation of bioactive compounds from Cola nitida pod.

Introduction: The quality characteristics and stability of phenolic by-products from Cola nitida wastes are critical factors for drug formulation and food nutraceutical applications.

Objectives: In this study, the effect of electromagnetic-based microwave-reflux extraction on the total phenolic content, antioxidant capacity, morphological characteristics, physisorption and chromatographic phenolic profiles were successfully investigated. These physicochemical analyses are often employed in the standardisation of dried herbal and food nutraceutical products.

leaf fractions attenuated venom-induced cellular dysfunctions via modulation of Nrf2 and inflammatory signalling pathways in rats.

envenoming could activate multiple pathways linked to haematotoxic, neurological, and antioxidant systems dysfunctions. has been used in the management of different snake venom-induced toxicities, but there is no scientific information on its antivenom effects against . This study thus, investigated the antivenom activities of different extract partitions of leaves against envenoming Forty five male rats were divided into nine groups (n = 5).

Shedding proportion of -like oocysts in feral cats and soil contamination in Oyo State, Nigeria.

Toxoplasmosis, a disease caused by the intracellular protozoan parasite is transmitted through several hosts with cats serving as its definitive host. Oocysts are released with cat faeces into the environment ( soil); an important medium in its transmission. The level of soil contamination with oocysts is an indicator of the level of on- going transmission.

leaf partitions ameliorate alloxan-induced pathophysiological complications via antioxidant mechanisms in diabetic rats.

(Wild.) Amin ex. Jeffery belongs to family Asteracaea.

Simultaneous Adsorption of Malachite Green and Methylene Blue Dyes in a Fixed-Bed Column Using Poly(Acrylonitrile-Co-Acrylic Acid) Modified with Thiourea.

Proper remediation of aquatic environments contaminated by toxic organic dyes has become a research focus globally for environmental and chemical engineers. This study evaluates the adsorption potential of a polymer-based adsorbent, thiourea-modified poly(acrylonitrile--acrylic acid) (T-PAA) adsorbent, for the simultaneous uptake of malachite green (MG) and methylene blue (MB) dye ions from binary system in a continuous flow adsorption column. The influence of inlet dye concentrations, pH, flow rate, and adsorbent bed depth on adsorption process were investigated, and the breakthrough curves obtained experimentally.

Drying characteristics of yam slices () in a convective hot air dryer: application of ANFIS in the prediction of drying kinetics.

This study applied Adaptive Neuro-Fuzzy Inference System (ANFIS) to predict the moisture ratio (MR) during the drying process of yam slices () in a hot air convective dryer. Also the effective diffusivity, activation energy, and rehydration ratio were calculated. The experiments were carried out at three (3) drying air temperatures (50, 60, and 70 °C), air velocities (0.

Preparation of Ethylene Glycol Dimethacrylate (EGDMA)-Based Terpolymer as Potential Sorbents for Pharmaceuticals Adsorption.

Ethylene glycol dimethacrylate (EGDMA) is used as a crosslinker in poly(acrylonitrile (AN)--vinylbenzyl chloride (VBC)) to investigate the effect of long-chain crosslinker to the porosity of the terpolymer system. Poly(AN--EGDMA--VBC) is synthesized by using precipitation polymerization method and further hypercrosslinked by Friedel-Crafts reaction. FT-IR spectra of poly(AN--EGDMA--VBC) show that the absorption bands at ~1290 cm that are assigned to the C-Cl vibrations are almost disappeared in hypercrosslinked (HXL) poly(AN--EGDMA--VBC) polymers, confirming that the hypercrosslinking reaction is successful.