Synergistic Effect of Donepezil and Neurotropic B Vitamins on Dysregulated Antioxidant, Inflammation and Neurotransmitter Status in Aluminium Chloride-Induced Neurotoxicity in Rats.

Combination therapy offers a promising advantage because they target multiple pathways involved in the pathogenesis and progression of Alzheimer's disease. This study aimed to investigate the synergistic effect of donepezil and each of vitamin B12, vitamin B6 and vitamin B1 on aluminium chloride (AlCl)-induced neurotoxicity in rats. Fifty-four rats were divided into nine groups of six.

Neuroprotective Effects of Folic Acid: A Review.

Folic acid also known as folate and vitamin B9 is of the class of B complex vitamins. It is crucial for homeostatic function of the biological system and is not endogenously produced. It is medically approved for the treatment of megaloblastic anemia.

The Potential of Plant Polysaccharides and Chemotherapeutic Drug Combinations in the Suppression of Breast Cancer.

Breast cancer is the most common cancer affecting women worldwide. The associated morbidity and mortality have been on the increase while available therapies for its treatment have not been totally effective. The most common treatment, chemotherapy, sometimes has dangerous side effects because of non-specific targeting, in addition to poor therapeutic indices, and high dose requirements.

Management of Alzheimer's disease and related neurotoxic pathologies: Role of thiamine, pyridoxine and cobalamin.

Alzheimer's disease (AD) remains one of the most debilitating disease and most common neurological disorder in the world at large. However, with many years of multiple research and billions of dollars invested for the purpose of research, not many therapeutic options exist for the management of this disease. As at 2023, the number has only increased to 7, one of which is a combination of two existing therapies.

Gastroprotective mechanism of on ethanol-induced gastric ulcer in Wistar rats inflammatory, antioxidant, and H/K-ATPase inhibition-mediated pathways.

The increase in the incidence of gastric ulcer (GU) has posed major threat on public health. This research aimed to evaluate gastroprotective properties of the aqueous leaf extract of (AETT) in ethanol-induced gastric ulceration. GU was induced oral administration of single dose of 5 mLkg of 90% ethanol in rats and protection of 200 mgkg bw of AETT and 20 mgkg bw of omeprazole was investigated for 14 d oral treatment.

Biologically Synthesized Gold Nanoparticles Mitigate Aluminum Chloride-Induced Nephrotoxicity via Downregulation of iNOX, LCN2 and IL-1β Genes.

Humans are constantly exposed to aluminum (Al), an environmental toxicant, and its accumulation in the glomerular could lead to acute kidney disease. Biologically synthesized gold nanoparticles (AuNPs) have been employed in the management of kidney disorders. This study assessed the modulatory effect of AuNPs mediated by Hibiscus sabdariffa (HS) on aluminum chloride (AlCl)-induced nephrotoxicity in rats.

Water-soluble phenolics from fruits as potential reno-protective agent against cisplatin-induced toxicity: pre- and post-treatment strategies.

Nephrotoxicity is the major side effect of cisplatin, an effective platinum-based chemotherapeutic drug that is applicable in the treatment of several solid-tissue cancers. Studies have indicated that certain water-soluble phenolics offer renal protection. Thus, this study investigates the role of pre and post-treatment of rats with water-soluble phenolics from (PdP) against nephrotoxicity induced by cisplatin.

Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis in the Pathology of Alzheimer's Disease.

Alzheimer's disease (AD) accounts for a major statistic among the class of neurodegenerative diseases. A number of mechanisms have been identified in its pathogenesis and progression which include the amyloid beta (Aβ) aggregation, hyperphosphorylation of tau protein, oxidative stress, endoplasmic reticulum (ER) stress and apoptosis. These processes are interconnected and contribute significantly to the loss of neurons, brain mass and consequential memory loss and other cognitive difficulties.

Nutritive evaluation of dried cabbage (Brassica oleracea var. capitata) waste meal as feed for grower-finisher pigs.

This research investigated the nutritive value of dried cabbage waste meal (CWM) as feed for grower-finisher pigs. One hundred crossbred (Large white X Landrace; 86.10 ± 0.

Microbiological quality of water samples obtained from water sources in Ishaka, Uganda.

Objectives: This study aimed to evaluate the microbiological quality of water sources in Ishaka division, Bushenyi district.

Methods: Water from taps, wells and springs were sampled for the cross-sectional investigation. The enumeration and identification of microbes ( and total coliforms) in water samples were carried out using a variety of methods.

Damping and Stiffness Analysis of Sandwich Beam with 3D-Printed Honeycomb Core Filled with Magnetorheological Elastomer (MRE): An Experimental Approach.

The current study focuses on the production and experimental examination of sandwich beams consisting of an aluminum face sheet and 3D-printed honeycomb cores that are filled with magnetorheological elastomer (MRE). These cores are loaded with different ratios of (75/25)% and (50/50)% elastomer and magnetic particles, measured by weight. In order to ascertain the dynamic characteristics of sandwich beams, the constructed specimens were subjected to classic shock (free vibration) experiments, and these experiments were conducted under two conditions: with and without the application of a changing magnetic field at the free end and center of the beam.

Burden of Traumatic Spinal Cord Injury in Sub-Saharan Africa: A Scoping Review.

Introduction: With a varying annual incidence across populations, traumatic spinal cord injury (TSCI) remains a public health concern of utmost importance, especially in developing countries with an incidence rate ranging from 12.7 to 29.7 per million people and a postulated increase in the number of patients living with undesirable complications of this condition.

Bioactivities of Garcinia kola enzymatic hydrolysates at different enzyme-substrate ratios.

Natural products, such as enzymatic hydrolysates and bioactive peptides from dietary sources, are safe alternatives to synthetic compounds linked to various deleterious effects. The purpose of this study is to determine the in vitro bioactivities (antioxidant and anti-inflammatory activities) of Garcinia kola seeds enzymatic hydrolysates (GKPHs) at different enzyme (pepsin)-substrate ratios. G.

GC-MS analysis of aqueous extract of and ameliorative potential of its biosynthesized gold nanoparticles against cadmium-induced kidney damage in rats.

Plants possess compounds serving as reducing agents for green synthesis of gold nanoparticles (AuNPs), which is currently considered for biomedical application. Exposure to cadmium (Cd) can affect the functional integrity of the several organs such as kidney and liver. (NL) is known for its several medicinal properties, including its protective role against tissue damages.

Xylopia aethiopica suppresses markers of oxidative stress, inflammation, and cell death in the brain of Wistar rats exposed to glyphosate.

The herbicide "Roundup" is used extensively in agriculture to control weeds. However, by translocation, it can be deposited in plants, their proceeds, and the soil, thus provoking organ toxicities in exposed individuals. Neurotoxicity among others is one of the side effects of roundup which has led to an increasing global concern about the contamination of food by herbicides.

Association of Meteorological Factors With COVID-19 During Harmattan in Nigeria.

Harmattan is a season of dry, cold, dusty wind, and haze that is peculiar to West Africa. This season and COVID-19 share common conditions such as malaise and respiratory issues like as runny nose, cough and sneezing, and raise a question of a possible relationship that begs to be answered. This study investigated whether the meteorological factors of humidity and wind speed during harmattan have association with COVID-19 incidence and mortality in the 2 major COVID-19 epicenters of Lagos state and the Federal Capital Territory (FCT) in southern and northern geopolitical regions of Nigeria respectively.

In vitro antioxidant and anti-inflammatory properties of Artocarpus altilis (Parkinson) Fosberg (seedless breadfruit) fruit pulp protein hydrolysates.

Protein hydrolysates from dietary sources possess many physiological and biological properties. Artocarpus altilis is an evergreen multipurpose plant with many benefits. Therefore, this study evaluates in vitro antioxidant and anti-inflammatory properties of A.

Synthesized gold nanoparticles mediated by extract down-regulate KIM-1/NGAL genes and inhibit oxidative stress in cadmium-induced kidney damage in rats.

Cadmium (Cd) exposure induces kidney damage by mediating oxidative stress and inflammation. In this study, the role of -gold nanoparticles (-AuNPs) in down-regulating kidney injury molecules-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) genes and inhibiting oxidative stress in Cd-induced kidney damage in rats was investigated. Thirty male Wistar rats were distributed randomly into six groups ( = 5).

Short- and long-term effect of colorectal cancer targeting peptides conjugated to gold nanoparticles in rats' liver and colon after single exposure.

Peptides play important roles in the diagnosis, prognostic predictors, and treatment of various kinds of cancer. Peptides (p.C, p.

D-ribose-L-cysteine exhibits neuroprotective activity through inhibition of oxido-behavioral dysfunctions and modulated activities of neurotransmitters in the cerebellum of Juvenile mice exposed to ethanol.

Alcohol exposure to the cerebellum has been known to trigger cerebellar dysfunctions through several mechanisms. This present study was designed to evaluate the repealing effect of D-ribose-L-cysteine (DRLC) on alcohol-induced cerebellar dysfunctions in juvenile BALB/c mice. The animals were randomly divided into 4 groups (=10 per group).

Dynamic Behavior of Sandwich Structures with Magnetorheological Elastomer: A Review.

Magnetorheological (MR) materials are classified as smart materials that can alter their rheological features once exposed to peripheral magnetic fields. MR materials have been a standard and one of the primary smart materials for the last few decades due to their outstanding vibration control performance in adaptive sandwich structures and systems. This paper reviews the vibration suppression investigations of flexible constructions using MR elastomers (MREs).

Combined effect of metformin and gallic acid on inflammation, antioxidant status, endoplasmic reticulum (ER) stress and glucose metabolism in fructose-fed streptozotocin-induced diabetic rats.

Over time, diabetes patients usually need combination therapy involving two or more agents, including phytonutrients to attain therapeutic targets. The purpose of this research is to elucidate the combined effect of metformin and gallic acid (GA) on glucose metabolism, inflammation as well as oxidative and endoplasmic reticulum (ER) stresses in fructose-fed diabetic rats. Thirty-five rats of Wistar strain were arbitrarily distributed into five groups, each containing seven animals as follows: normal control, diabetic control, groups administered 100 mg/kg bw metformin only, 50 mg/kg bw gallic acid only and a combination of both.

Assessing Public Health Workforce Informatics Competencies: A Study of 3 District Health Departments in Georgia.

Context: Despite the increased recognition of the importance of having informatics-competent public health professionals, the competency level of the public health workforce in public health informatics (PHI) has not been examined extensively in the literature.

Objective: The purpose of this study was to assess public health workforce informatics competencies in select Georgia health districts and determine the correlates of PHI proficiency.

Methods: This study is based on a cross-sectional quantitative study design.

Biochemical assessment of the neurotoxicity of gold nanoparticles functionalized with colorectal cancer-targeting peptides in a rat model.

The application of gold nanoparticle-peptide conjugates as theranostic agents for colorectal cancer shows much promise. This study aimed at determining the neurotoxic impact of 14 nm gold nanoparticles (AuNPs) functionalized with colorectal cancer-targeting peptides (namely p.C, p.

Ameliorating activity of polyphenolic-rich extracts of L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats.

Objectives: To assess the ameliorative activity of polyphenolic-rich extracts of leaves on β-cell dysfunction in type-II diabetes (T2DM).

Methods: Total phenolic and flavonoid contents; α-amylase and α-glucosidase inhibitory actions and qualitative analysis of the bioactive compounds of the polyphenolic-rich extract of leaves were investigated using gas chromatography-mass spectroscopy (GC-MS). Diabetes mellitus (DM) was induced by single intraperitoneal injection of streptozotocin (60 mg/kg body weight) and the rats were orally given bound phenolic (BPE) and free phenolic extracts (FPE) of (B.