Antidiabetes and antioxidant potential of Schiff bases derived from 2-naphthaldehye and substituted aromatic amines: Synthesis, crystal structure, Hirshfeld surface analysis, computational, and studies.

Three Schiff bases were synthesised by the condensation reaction between 2-napthaldehyde and aromatic amines to afford -mesityl-1-(naphthalen-2-yl)methanimine (), ()--(2,6-dimethylphenyl)-1-(naphthalen-2-yl)methanimine () and -(2,6-diisopropylphenyl)-1-(naphthalen-2-yl)methanimine (). The synthesised compounds were characterised using UV-visible, NMR (C & H), and Fourier transform infrared spectroscopic methods while their purity was ascertained by elemental analysis. Structural analysis revealed that the naphthalene ring is almost coplanar with the imine functional group as evident by C1-C10-C11-N1 torsion angles of 176.

Ni and Cu complexes of N-(2,6-dichlorophenyl)-N-mesityl formamidine dithiocarbamate structural and functional properties as CYP3A4 potential substrates.

Metal compounds continued to attract diverse applications due to their malleability in several capacities. In this study, we present our findings on the crystal structures and functional properties of Ni and Cu complexes of N'-(2,6-dichlorophenyl)-N-mesitylformamidine dithiocarbamate (L) comprising [Ni-(L)] (1) and [Cu-(L)] (2) with a four-coordinate metal center. We established the two complex structures through H and C nuclear magnetic resonance (NMR), elemental, and single-crystal X-ray analysis.

The link between relative stability constant of DNA- and BSA-chromenopyrimidine complexes and cytotoxicity towards human breast cancer cells (MCF-7).

In this study, we synthesized and characterized ten chromenopyrimidine derivatives using analytical and spectroscopic methods. Studies on DNA and albumin binding affinity, as well as cytotoxicity tests on human breast cancer (MCF-7) cells, of the chromenopyrimidines, were conducted. The natural logarithm of the relative stability constant of DNA- and BSA-chromenopyrimidine complexes [ln(/)] was used as a criterion for selecting compounds for cytotoxicity studies.

Silver(I) pyridinyl complexes with benzothiazole, thiophene, and furan moieties: DNA/protein-binding, antibacterial, antioxidant, and anticancer studies.

We have synthesized and characterized nine Ag(I) complexes of Schiff bases containing thiophene, furan, and pyridine moieties for in vitro antibacterial, antioxidant, anticancer activities, and DNA/bovine serum albumin (BSA) binding studies. Based on the analytical and spectral analyses, a linear geometry was proposed for all the Ag(I) complexes, except for one (with the furan moiety), which formed a distorted T-shaped geometry. UV-vis absorption studies on the interactions of calf thymus-DNA (CT-DNA) with the nine Ag(I) complexes pointed to an intercalative binding mode.

A study of structure-activity relationship and anion-controlled quinolinyl Ag(I) complexes as antimicrobial and antioxidant agents as well as their interaction with macromolecules.

In this communication, we feature the synthesis and in-depth characterization of a series of silver(I) complexes obtained from the complexation of quinolin-4-yl Schiff base ligands ((E)-2-((quinolin-4-ylmethylene)amino)phenol L, 2-(quinolin-4-yl)benzo[d]thiazole L, (E)-N-(2-fluorophenyl)-1-(quinolin-4-yl)methanimine L, (E)-N-(4-chlorophenyl)-1-(quinolin-4-yl)methanimine L, (E)-1-(quinolin-4-yl)-N-(p-tolyl)methanimine L, (E)-1-(quinolin-4-yl)-N-(thiophen-2-ylmethyl)methanimine L) and three different silver(I) anions (nitrate, perchlorate and triflate). Structurally, the complexes adopted different coordination geometries, which included distorted linear or distorted tetrahedral geometry. The complexes were evaluated in vitro for their potential antibacterial and antioxidant activities.

Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities.

A series of fifteen silver (I) quinoline complexes - have been synthesized and studied for their biological activities. - were synthesized from the reactions of quinolinyl Schiff base derivatives - (obtained by condensing 2-quinolinecarboxaldehyde with various aniline derivatives) with AgNO, AgClO and AgCFSO. - were characterized by various spectroscopic techniques and the structures of [Ag()]NO, [Ag()]ClO, [Ag()]ClO, [Ag()]CFSO and [Ag()]CFSO were unequivocally determined by single crystal X-ray diffraction analysis.

Aryl variation and anion effect on CT-DNA binding and in vitro biological studies of pyridinyl Ag(I) complexes.

Synthesis and spectroscopic characterization of five ligands ((E)-2-((pyridin-2-ylmethylene)amino)phenol L1, 2-(pyridin-2-yl)benzo[d]thiazole L2, (E)-N-(2-fluorophenyl)-1-(pyridin-2-yl)methanimine L3, (E)-1-(pyridin-2-yl)-N-(p-tolyl)methanimine L4 and (E)-1-(pyridin-2-yl)-N-(thiophen-2-ylmethyl)methanimine L5 along with fifteen silver(I) complexes of L1 - L5, with a general formula [AgL]X (L = Schiff base and X = NO, ClO or CFSO) is reported. The structures of complexes [Ag(L4)]NO, [Ag(L5)]NO, [Ag(L3)]ClO, [Ag(L4)]ClO and [Ag(L5)]CFSO were determined unequivocally by single crystal X-ray diffraction analysis. Calf-thymus deoxyribonucleic acid (CT-DNA), bovine serum albumin (BSA) binding studies, antioxidant, and antibacterial studies were performed for all complexes.